Venugopalan C S, O'Rourke Y M, Tucker T A
J Pharm Sci. 1985 Oct;74(10):1120-2. doi: 10.1002/jps.2600741025.
The potential value of lithium as a bronchodilator has been evaluated by in vitro methods using guinea pig tracheal spirals and lung parenchymal strips. The use of twin spirals and strips prepared by splitting the tissues longitudinally into two equal halves has been used to minimize animal variations. The cumulative concentration-effect relationships of isoproterenol have been determined on these twin tissues contracted submaximally with histamine. The responses of the twin tissues did not significantly differ. The cumulative concentration-effect relationships of lithium on guinea pig tracheal spirals and lung parenchymal strips have been evaluated and compared with those of isoproterenol. Lithium showed a dose-dependent relaxation on both tissues. However, the potency of lithium to produce a relaxant effect was significantly lower than isoproterenol. The relaxing effect of lithium on parenchyma was significantly higher than that on the trachea. The lithium-induced inhibitory effect on the contractile responses of tracheal spirals and lung parenchymal strips to histamine before and after incubating the tissues with lithium for 15 min has been determined. Lithium significantly reduced the contractile effect of histamine on both tissues. These findings suggest a potential clinical applicability of lithium for treating airway hyperresponsiveness.
锂作为支气管扩张剂的潜在价值已通过体外方法进行评估，该方法使用豚鼠气管螺旋条和肺实质条。通过将组织纵向切成两个相等的半条来制备双螺旋条和双条，以尽量减少动物个体差异。在这些用组胺亚最大收缩的双组织上测定了异丙肾上腺素的累积浓度-效应关系。双组织的反应没有显著差异。评估了锂对豚鼠气管螺旋条和肺实质条的累积浓度-效应关系，并与异丙肾上腺素的进行了比较。锂对两种组织均呈现剂量依赖性舒张作用。然而，锂产生舒张作用的效力显著低于异丙肾上腺素。锂对实质组织的舒张作用显著高于对气管的作用。已确定在将组织用锂孵育15分钟前后，锂对气管螺旋条和肺实质条对组胺收缩反应的抑制作用。锂显著降低了组胺对两种组织的收缩作用。这些发现提示锂在治疗气道高反应性方面具有潜在的临床应用价值。
