Crook Triston B, Sitto Mina M, Lindberg Ethan J, Hoopes Phillip C, Moshirfar Majid
Noorda College of Osteopathic Medicine, Provo, UT, USA.
These authors contributed equally to this work.
Med Hypothesis Discov Innov Ophthalmol. 2025 Jul 31;14(2):28-39. doi: 10.51329/mehdiophthal1521. eCollection 2025 Summer.
Recent innovations in intraocular lens (IOL) design have introduced extended depth of focus lenses, which has shown promise in improving visual acuity at multiple distances while preserving the distance vision provided by a standard monofocal IOL. This study aimed to evaluate the visual outcomes of TECNIS Eyhance, a monofocal IOL with enhanced intermediate function, and a standard TECNIS monofocal 1-piece IOL, and to review published studies comparing the clinical performance between the TECNIS Eyhance and standard IOLs.
A retrospective analysis was conducted on patients who underwent cataract extraction with bilateral implantation of either TECNIS Eyhance IOLs or TECNIS Monofocal 1-Piece IOLs. Primary outcomes included monocular and binocular uncorrected distance visual acuity (UDVA), uncorrected near visual acuity (UNVA), and corrected distance visual acuity (CDVA), and manifest refraction. Outcomes such as glare, halos, and dry eye were also assessed. A literature review was performed to identify studies evaluating the clinical outcomes of TECNIS Eyhance and standard TECNIS monofocal IOLs.
In total 108 patients (216 eyes) underwent bilateral implantation with either TECNIS Eyhance (104 eyes) or TECNIS Monofocal 1-Piece (112 eyes) IOLs. The mean (standard deviation [SD]) binocular UNVA was better in the Eyhance group at 1 month (0.18 [0.13] logMAR) compared to the standard monofocal group (0.24 [0.14] logMAR; < 0.05). A greater proportion of Eyhance patients achieved binocular UNVA of 20/25 or better (46.9% vs 21.8%; < 0.01), and 20/32 or better (65.3% vs 45.5%; < 0.05). However, there was no significant difference for 20/20 visual acuity (20.4% vs 18.2%; > 0.05). No significant differences were observed in postoperative UDVA or CDVA between groups (both > 0.05). The mean (SD) monocular UNVA showed a slight, but non-significant, advantage in the Eyhance group (0.26 [0.15] logMAR vs 0.29 [0.15] logMAR; > 0.05). Eyhance eyes demonstrated less residual refractive cylinder at 1 month ( < 0.01), which may be attributed to a higher rate of toric IOL use ( < 0.01). Patient-reported visual symptoms did not differ between groups. Thirteen studies were identified that compared the Eyhance and standard monofocal IOLs. Across the studies analyzed, the Eyhance group showed better monocular and binocular UNVA with mean (SD) differences of - 0.10 (0.20) logMAR and - 0.10 (0.21) logMAR, respectively (both < 0.01), as well as improved binocular uncorrected intermediate visual acuity (UIVA) (mean difference [SD]: -0.10 [0.18] logMAR; < 0.01). These studies also showed low rates of glare and halos for both IOLs.
Patients receiving the TECNIS Eyhance IOL had better binocular UNVA compared to those with a standard monofocal IOL, consistent with published literature. The Eyhance IOL also showed better binocular UIVA and monocular UNVA across the studies reviewed. Both enhanced and standard monofocal IOLs demonstrate excellent distance vision and have similar levels of photic phenomena. Nevertheless, the Eyhance IOL shows promising potential for improving intermediate and near vision.
人工晶状体（IOL）设计的最新创新引入了扩展焦深晶状体，在提高多距离视力的同时保留标准单焦点IOL提供的远视力方面显示出前景。本研究旨在评估具有增强中视力功能的单焦点IOL TECNIS Eyhance和标准的TECNIS单焦点一体式IOL的视觉效果，并回顾比较TECNIS Eyhance与标准IOL临床性能的已发表研究。
对接受白内障摘除并双侧植入TECNIS Eyhance IOL或TECNIS单焦点一体式IOL的患者进行回顾性分析。主要结局包括单眼和双眼未矫正远视力（UDVA）、未矫正近视力（UNVA）、矫正远视力（CDVA）和显验光。还评估了眩光、光晕和干眼等结局。进行文献综述以确定评估TECNIS Eyhance和标准TECNIS单焦点IOL临床结局的研究。
共有108例患者（216只眼）接受了双侧植入，其中104只眼植入TECNIS Eyhance，112只眼植入TECNIS单焦点一体式IOL。与标准单焦点组相比，Eyhance组在1个月时的平均（标准差[SD]）双眼UNVA更好（0.18[0.13]logMAR比0.24[0.14]logMAR；P<0.05）。Eyhance组中达到双眼UNVA为20/25或更好的患者比例更高（46.9%对21.8%；P<0.01），以及达到20/32或更好的比例更高（65.3%对45.5%；P<0.05）。然而，在20/20视力方面无显著差异（20.4%对18.2%；P>0.05）。两组术后UDVA或CDVA均无显著差异（均P>0.05）。Eyhance组的平均（SD）单眼UNVA显示出轻微但不显著的优势（0.26[0.15]logMAR对0.29[0.15]logMAR；P>0.05）。Eyhance眼在1个月时的残余屈光柱镜较少（P<0.01），这可能归因于更高的散光IOL使用率（P<0.01）。患者报告的视觉症状在两组之间无差异。确定了13项比较Eyhance和标准单焦点IOL的研究。在所分析的研究中，Eyhance组显示出更好的单眼和双眼UNVA，平均（SD）差异分别为-0.10（0.20）logMAR和-0.10（0.21）logMAR（均P<0.01），以及改善的双眼未矫正中视力（UIVA）（平均差异[SD]：-0.10[0.18]logMAR；P<0.01）。这些研究还显示两种IOL的眩光和光晕发生率均较低。
与接受标准单焦点IOL的患者相比，接受TECNIS Eyhance IOL的患者双眼UNVA更好，与已发表文献一致。在所回顾的研究中，Eyhance IOL还显示出更好的双眼UIVA和单眼UNVA。增强型和标准单焦点IOL均表现出出色的远视力，并且有相似水平的光学现象。尽管如此，Eyhance IOL在改善中视力和近视力方面显示出有前景的潜力。
