Wang Yan, Sui Bailu, Zhang Ying, Fang Liyuan, Xie Yi, Fang Yuhang, Wang Runxi
Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Graduate School, Beijing University of Chinese Medicine, Beijing, China.
Front Immunol. 2025 Jul 25;16:1583522. doi: 10.3389/fimmu.2025.1583522. eCollection 2025.
Acupuncture and moxibustion have been shown to be safe and effective methods for bidirectional immunomodulatory function. Clinical practice and many studies have shown that acupuncture and moxibustion have a certain clinical effect on immune promotion in patients with malignant tumors.
Eight electronic databases were searched systematically for articles published through December 31, 2024. Study Selection Randomized controlled trial studies (RCTs) that reported The number of T lymphocytes cells in patients with malignant tumors who received acupuncture and/or moxibustionon treatment were included. For continuous variables, effect estimates were calculated as mean difference (MD); and for dichotomous variables, the risk ratio (RR) was calculated. A funnel plot was used to analyze potential publication bias.
33 studies involving 2610 participants were included. Patients who received acupuncture and/or moxibustion treatment had higher CD3, CD4, CD4/CD8 and natural killer (NK) cell levels, but lower CD8 levels. At the same time, the anti-tumor treatment effect was better than that of the control group.
Evidence from this meta-analysis, acupuncture and moxibustion can enhance the immune function and improve the prognosis of malignant tumor patients. Further studies are recommended to support and confirm these findings.
https://www.crd.york.ac.uk/prospero/, identifier CRD42023465759.
针灸已被证明是具有双向免疫调节功能的安全有效方法。临床实践和许多研究表明，针灸对恶性肿瘤患者的免疫促进具有一定的临床效果。
系统检索了8个电子数据库中截至2024年12月31日发表的文章。研究选择纳入报告接受针灸和/或艾灸治疗的恶性肿瘤患者T淋巴细胞数量的随机对照试验研究（RCT）。对于连续变量，效应估计值计算为平均差（MD）；对于二分变量，计算风险比（RR）。采用漏斗图分析潜在的发表偏倚。
纳入33项研究，共2610名参与者。接受针灸和/或艾灸治疗的患者CD3、CD4、CD4/CD8和自然杀伤（NK）细胞水平较高，但CD8水平较低。同时，抗肿瘤治疗效果优于对照组。
这项荟萃分析的证据表明，针灸可以增强恶性肿瘤患者的免疫功能并改善预后。建议进一步研究以支持和证实这些发现。
