Nguyen Khanh Ha, Trinh Thi Thanh
On-demand General Medical Day Care Department at Hanoi Oncology Hospital, Hanoi, Vietnam.
Rare Tumors. 2025 Aug 9;17:20363613251366937. doi: 10.1177/20363613251366937. eCollection 2025.
Inguinal sebaceous gland carcinoma is extremely rare, often mistaken for inflammatory skin lesions, leading to delays in diagnosis and treatment. We reported a rare clinical case of a 59-year-old male patient who presented to the hospital with a lesion in the left groin area, characterized by raised nodules, gradually increasing in size, accompanied by itching. The disease had been progressing for over 3 years, with no prior history of sexually transmitted infections or urinary tract infections. The patient underwent wide local excision surgery with lymph node dissection. Histopathological findings and postoperative immunohistochemistry confirmed sebaceous gland carcinoma presenting in the left groin area with metastasis to 2 groin lymph nodes. After surgery, the patient underwent adjuvant radiation therapy. At the end of the radiation therapy, no tumor recurrence was detected, and no radiation-related toxicity was noted. The patient was discharged and followed up regularly. The patient remains stable after 6 months of follow-up, with no signs of disease recurrence or treatment complications. In conclusion, inguinal sebaceous gland carcinoma is sporadic, so clinical features and optimal treatment methods are poorly understood. Further research is warranted to clarify this rare condition.
腹股沟皮脂腺癌极为罕见，常被误诊为炎性皮肤病变，导致诊断和治疗延误。我们报告了一例罕见的临床病例，一名59岁男性患者因左腹股沟区出现病变前来就诊，病变表现为隆起的结节，大小逐渐增大，伴有瘙痒。该病已进展3年多，既往无性传播感染或尿路感染病史。患者接受了广泛局部切除手术及淋巴结清扫术。组织病理学检查结果及术后免疫组化证实为左腹股沟区皮脂腺癌，并伴有2个腹股沟淋巴结转移。术后患者接受了辅助放疗。放疗结束时，未检测到肿瘤复发，也未发现放疗相关毒性反应。患者出院并定期随访。随访6个月后患者情况稳定，无疾病复发或治疗并发症迹象。总之，腹股沟皮脂腺癌是散发性的，因此对其临床特征和最佳治疗方法了解甚少。有必要进一步研究以阐明这种罕见疾病。
