Mohd Noor Asma Amirah, Abdul Hadi Azwanis, Che Abdul Rahim Abdul Rahman
MBBS, Department of Family Medicine, Kulliyyah of Medicine, International Islamic University Malaysia, Kuantan, Pahang, Malaysia.
MBChB, MMed (Family Medicine), Department of Family Medicine, Kulliyyah of Medicine, International Islamic University Malaysia, Kuantan, Pahang, Malaysia. E-mail:
Malays Fam Physician. 2025 Jul 9;20:42. doi: 10.51866/cr.668. eCollection 2025.
Palmoplantar keratoderma (PPK) is a dermatological disorder characterised by excessive thickening of the palms and soles, encompassing more than 20 conditions. The disease is often misdiagnosed in primary care settings, leading to unnecessary treatments and delays. We present the case of a 3-year-old girl with skin thickening on both her palms and soles persisting for 2 years, initially believed to be an acquired condition. Subsequent evaluation revealed a family history of similar skin lesions. This case report highlights the crucial role of family physicians in differentiating hereditary from acquired PPK, especially in settings where advanced testing is unavailable. Implementing a structured diagnostic approach at the primary care level can significantly improve patient management and reduce morbidities and healthcare costs. This case contributes to the existing knowledge in this field, where hereditary PPK remains underexplored.
掌跖角化病（PPK）是一种皮肤病，其特征是手掌和脚底过度增厚，涵盖20多种病症。该疾病在初级保健机构中常常被误诊，导致不必要的治疗和延误。我们报告一例3岁女童，其手掌和脚底皮肤增厚持续2年，最初被认为是后天性疾病。随后的评估发现有类似皮肤病变的家族史。本病例报告强调了家庭医生在区分遗传性和后天性PPK方面的关键作用，尤其是在无法进行先进检测的情况下。在初级保健层面实施结构化诊断方法可显著改善患者管理，降低发病率和医疗成本。本病例为该领域的现有知识做出了贡献，在该领域遗传性PPK仍未得到充分研究。
