利用微生物合成生物学生产粘康酸的最新进展。
Recent advances of muconic acid production using microbial synthetic biology.
作者信息
Liu Xiqiang, Lu Jintao, Chen Siqi, Wang Mingyang, Shah Aamer Ali, Gong Chunjie
机构信息
Key Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province), National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, 430068, People's Republic of China.
Department of Microbiology, Faculty of Biological Sciences, Quaid-i-Azam University, lslamabad, 45320, Pakistan.
出版信息
Arch Microbiol. 2025 Aug 11;207(9):221. doi: 10.1007/s00203-025-04419-8.
Muconic acid is a high-value intermediate with unique properties. Traditional methods for muconic acid production showed some disadvantages including expensive raw materials, environmentally sensitive, and high concentration of heavy metal catalysts. With the development of synthetic biology, bio-strategies for muconic acid production have been widely studied. In this paper, key advances in muconic acid production using synthetic biology are highlighted. Furthermore, strategies for improving muconic acid production have been discussed, including cofactor engineering, modular co-culture, and artificial intelligence-assisted enzyme optimization. Given the significant advantages of biosynthesis in clean production and cost control, the paper concludes with an analysis of the economic and technical feasibility of microbial muconic acid production.
粘康酸是一种具有独特性质的高价值中间体。传统的粘康酸生产方法存在一些缺点，包括原材料昂贵、对环境敏感以及重金属催化剂浓度高。随着合成生物学的发展，利用生物策略生产粘康酸已得到广泛研究。本文重点介绍了利用合成生物学生产粘康酸的关键进展。此外，还讨论了提高粘康酸产量的策略，包括辅因子工程、模块化共培养和人工智能辅助酶优化。鉴于生物合成在清洁生产和成本控制方面的显著优势，本文最后分析了微生物生产粘康酸的经济和技术可行性。
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