Beule Achim G
HNO-Uniklinik Münster, Klinik und Poliklinik für Hals-Nasen-Ohrenkrankheiten, Universitätsmedizin Münster, Kardinal-von-Galen-Ring 10, 48149, Münster, Deutschland.
Klinik und Poliklinik für Hals-Nasen-Ohrenkrankheiten, Universitätsmedizin Greifswald, Greifswald, Deutschland.
HNO. 2025 Sep;73(9):615-621. doi: 10.1007/s00106-025-01660-x. Epub 2025 Aug 11.
The results of a scoping review on the current state of scientific knowledge in relation to the various anatomical areas from the nasopharynx to the ear are presented. In brief, foreign bodies in the area of the outer ear (hearing aids, piercings) change the microbiome and favor a moist environment. Middle ear infections also lead to changes in the fecal microbiome. Chronic middle ear effusions with otitis media are characterized by Corynebacteria in the nasopharynx. Diseases of the lower respiratory tract are associated with a reduction in diversity in the microbiome of tympanic effusions. Biofilms in the middle ear are associated with severe conductive hearing loss. In patients with a cholesteatoma, an altered middle ear microbiome could also be detected on the opposite side. Both protective and risk-increasing factors of the gut microbiome have been reported for sensorineural hearing loss. The relationship between the microbiome of the nasopharynx and the ear is heterogeneous depending on the underlying disease. In particular, the ability to influence hearing function through diet and the association with the gut microbiome also shed new light on diet as a preventive option for ENT specialists.
本文呈现了一项关于从鼻咽部到耳部各个解剖区域科学知识现状的范围综述结果。简而言之,外耳区域的异物(助听器、穿孔)会改变微生物群并营造潮湿环境。中耳感染也会导致粪便微生物群的变化。伴有中耳炎的慢性中耳积液的特征是鼻咽部存在棒状杆菌。下呼吸道疾病与鼓室积液微生物群多样性降低有关。中耳生物膜与严重的传导性听力损失有关。在胆脂瘤患者中,也可在对侧检测到中耳微生物群的改变。关于感音神经性听力损失,已报道了肠道微生物群的保护因素和风险增加因素。鼻咽部和耳部微生物群之间的关系因潜在疾病而异。特别是,通过饮食影响听力功能的能力以及与肠道微生物群的关联,也为耳鼻喉科专家将饮食作为一种预防选择提供了新的思路。