炎症性饮食、肠道微生物群与感音神经性听力损失：一项横断面和孟德尔随机化研究
Inflammatory diet, gut microbiota and sensorineural hearing loss: a cross-sectional and Mendelian randomization study.
作者信息
Wang Yixuan, Nie Jiayi, Yan Kaige, Wang Jing, Wang Xin, Zhao Yuxiang
机构信息
Department of Otolaryngology Head and Neck Surgery, Shaanxi Provincial People's Hospital, Xi'an, China.
Xi'an University of Technology, Xi'an, China.
出版信息
Front Nutr. 2024 Aug 16;11:1458484. doi: 10.3389/fnut.2024.1458484. eCollection 2024.
AIMS
Inflammatory diets can trigger chronic inflammation and affect gut microbiota. However, the relationship between dietary preferences and sensorineural hearing loss (SNHL) remains unclear. This study aims to elucidate the relationship between different dietary preferences and sensorineural deafness.
METHODS
The Dietary Inflammation Index (DII) and SNHL were defined by data from the National Health and Nutrition Examination Survey (NHANES), and exploring their relationship. Using Mendelian randomization (MR) to analyze the relationship between 34 dietary preferences, 211 gut microbiota, and SNHL.
RESULTS
Smooth curve fitting indicated that the risk of SNHL increased with increasing DII score when the DII score was greater than 5.15. MR results suggest that a diet including both oily and non-oily fish can substantially reduce the risk of SNHL. Additionally, six specific gut microbiota were found to have significant causal relationship with SNHL.
CONCLUSION
An inflammatory diet may increase the risk of developing SNHL. The observed relationship between fish consumption, gut microbiota, and SNHL suggests the existence of a gut-inner ear axis.
目的
炎症性饮食可引发慢性炎症并影响肠道微生物群。然而，饮食偏好与感音神经性听力损失（SNHL）之间的关系仍不明确。本研究旨在阐明不同饮食偏好与感音神经性耳聋之间的关系。
方法
通过美国国家健康与营养检查调查（NHANES）的数据定义饮食炎症指数（DII）和SNHL，并探索它们之间的关系。使用孟德尔随机化（MR）分析34种饮食偏好、211种肠道微生物群与SNHL之间的关系。
结果
平滑曲线拟合表明，当DII评分大于5.15时，SNHL的风险随着DII评分的增加而增加。MR结果表明，包含油性和非油性鱼类的饮食可大幅降低SNHL的风险。此外，发现六种特定的肠道微生物群与SNHL存在显著因果关系。
结论
炎症性饮食可能会增加发生SNHL的风险。观察到的鱼类消费、肠道微生物群与SNHL之间的关系表明存在肠道-内耳轴。
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