He Jiufang, Shi Yiping, Wang Xike
Medical School of Guizhou University, 550025 Guiyang, Guizhou, China.
Department of Pediatric Hematology, Zhujiang Hospital of Southern Medical University, 510282 Guangzhou, Guangdong, China.
Actas Esp Psiquiatr. 2025 Aug;53(4):802-812. doi: 10.62641/aep.v53i4.1975.
This investigation evaluates the interventional effects of electroencephalogram-based bioelectric stimulation (EBBS) on intellectual development and behavioural symptoms in children with autism spectrum disorder (ASD) and comorbid intellectual disability (ID).
By utilising a retrospective cohort design, the research team analysed 310 clinically diagnosed cases of ASD and ID that were stratified into two intervention groups: a conventional group (n = 163) receiving conventional interventions (behavioural applied behaviour analysis (ABA) therapy and structured instruction) and an observation group (n = 147) receiving the same behavioural interventions combined with EBBS. Before and following the treatment, the childhood autism rating scale (CARS), Montreal cognitive assessment (MoCA), developmental age and developmental quotient (DQ) and infants-junior middle school students' social-life abilities scale (S-M) were employed to assess symptom alleviation, cognitive capabilities and quality of life. The levels of serum 25-hydroxyvitamin D [25(OH)D], folic acid (FA) and brain-derived neurotrophic factor (BDNF) were also measured.
After treatment, the observation group showed significantly lower CARS scores; increased post-treatment serum levels of 25(OH)D, FA and BDNF; and improved MoCA scores than the conventional group (p < 0.05). Regarding developmental age and DQ, the observation group demonstrated significant improvements in the subscales of fine motor skills, language, adaptive ability and social interaction after intervention (p < 0.05). Additionally, the S-M total scores and all quality-of-life indicators were superior in the observation group (p < 0.05).
EBBS has the potential to collaboratively enhance the cognitive function, behavioural symptoms and quality of life of children with comorbid ASD and ID.
本研究评估基于脑电图的生物电刺激（EBBS）对自闭症谱系障碍（ASD）合并智力障碍（ID）儿童智力发育和行为症状的干预效果。
研究团队采用回顾性队列设计，分析了310例临床诊断为ASD和ID的病例，将其分为两个干预组：常规组（n = 163）接受常规干预（行为应用行为分析（ABA）疗法和结构化教学），观察组（n = 147）接受相同的行为干预并结合EBBS。治疗前后，采用儿童自闭症评定量表（CARS）、蒙特利尔认知评估量表（MoCA）、发育年龄和发育商（DQ）以及婴幼儿-初中生社会生活能力量表（S-M）评估症状缓解情况、认知能力和生活质量。同时还测量了血清25-羟维生素D [25(OH)D]、叶酸（FA）和脑源性神经营养因子（BDNF）水平。
治疗后，观察组的CARS评分显著低于常规组；治疗后血清25(OH)D、FA和BDNF水平升高；MoCA评分高于常规组（p < 0.05）。在发育年龄和DQ方面，观察组干预后在精细运动技能、语言、适应能力和社会交往等子量表上有显著改善（p < 0.05）。此外，观察组的S-M总分和所有生活质量指标均更优（p < 0.05）。
EBBS有可能协同改善ASD合并ID儿童的认知功能、行为症状和生活质量。
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