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反应性眼眶肌炎作为肾细胞癌的首发表现

Reactive Orbital Myositis as a First Manifestation of Renal Cell Carcinoma.

作者信息

Gómez-Benlloch Alba, Widmer-Pintos Julia N, Arnaldos-López Consuelo

机构信息

Department of Ophthalmology, Consorci Sanitari Integral, Barcelona, Spain.

Department of Ophthalmology, Hospital General de Granollers, Barcelona, Spain.

出版信息

Case Rep Ophthalmol. 2025 Jul 2;16(1):551-558. doi: 10.1159/000545489. eCollection 2025 Jan-Dec.

Abstract

INTRODUCTION

Orbital myositis (OM) is an inflammatory condition of the extraocular muscles, often idiopathic but occasionally associated with systemic diseases or malignancies. Secondary OM due to metastatic disease is rare. We report a case of OM as the initial manifestation of metastatic renal cell carcinoma, emphasizing the need for comprehensive evaluation of atypical ocular presentations.

CASE PRESENTATION

An 81-year-old male with a history of age-related macular degeneration presented with acute onset of pain and restricted movement in his left eye. Computed tomography imaging revealed an osteolytic lesion in the left sphenoid bone, causing reactive myositis. Further systemic evaluation identified a left renal mass with evidence of pulmonary and skeletal metastases. A core needle biopsy confirmed the diagnosis of metastatic renal cell carcinoma. Given the advanced disease stage, the patient was managed with palliative treatment. Despite medical interventions, he succumbed to the disease 6 months after symptom onset.

CONCLUSION

This case underscores the significance of considering malignancy in the differential diagnosis of OM, particularly in elderly patients with atypical ocular symptoms. Early recognition and systemic evaluation are crucial for timely diagnosis and management of underlying malignancies presenting with orbital involvement.

摘要

引言

眼眶肌炎(OM)是眼外肌的一种炎症性疾病,通常为特发性,但偶尔与全身性疾病或恶性肿瘤相关。转移性疾病所致的继发性眼眶肌炎罕见。我们报告一例眼眶肌炎作为转移性肾细胞癌的初始表现的病例,强调对非典型眼部表现进行全面评估的必要性。

病例介绍

一名有年龄相关性黄斑变性病史的81岁男性,出现左眼急性疼痛和活动受限。计算机断层扫描成像显示左侧蝶骨有溶骨性病变,导致反应性肌炎。进一步的全身评估发现左肾有肿块,并有肺和骨骼转移的证据。粗针活检确诊为转移性肾细胞癌。鉴于疾病分期较晚,对该患者进行了姑息治疗。尽管进行了医学干预,但他在症状出现6个月后死于该病。

结论

本病例强调在眼眶肌炎的鉴别诊断中考虑恶性肿瘤的重要性,特别是在有非典型眼部症状的老年患者中。早期识别和全身评估对于及时诊断和处理伴有眼眶受累的潜在恶性肿瘤至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbae/12338982/36fa6b08ae62/cop-2025-0016-0001-545489_F01.jpg

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