AlHabeeb Waleed, Kinsara Abdulhalim J, Alnouri Fahad, Alamri Hussein, Alshammeri Owayed, Albacker Turki, Al Faraidy Khalid, AlKashkari Wail, AlSaif Shukri, Balghith Mohammed, Borai Anwar A
Department of Cardiac Sciences, King Saud University, Riyadh, Saudi Arabia.
Department of Adult Cardiology, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia.
J Saudi Heart Assoc. 2025 Jul 16;37(3):10. doi: 10.37616/2212-5043.1444. eCollection 2025.
Cardiovascular disease (CVD) remains the leading cause of death and disability globally. In Saudi Arabia, the burden of CVD is exceptionally high, with age-standardized mortality and prevalence rates that far exceed global averages. The current CVD risk prediction tools have several limitations, and those classified as low to intermediate risk still experience cardiovascular events, underscoring the urgent need to address CVD through effective screening and prevention strategies.
A panel of Saudi experts reviewed evidence on the use of high-sensitivity cardiac troponin (hs-cTn) to enhance cardiovascular risk assessment among seemingly healthy individuals. Consensus recommendations tailored to the Saudi context were formulated based on the literature and local clinical practice, taking into consideration the characteristics of the Saudi population, local healthcare system, available resources and medical expertise.
Cardiac troponins are biomarkers of myocardial injury that can be detected in most seemingly healthy individuals using high-sensitivity assays. Studies have shown that measuring hs-cTn is a reliable predictor of future cardiovascular events in the general population. Consequently, incorporating hs-cTn into cardiovascular risk assessments could significantly improve the accuracy and effectiveness of existing risk stratification models. The experts highlighted the additional benefits of this approach compared to current risk assessment methods. This document aims to guide the integration of hs-cTn into cardiovascular risk assessment and prevention strategies for seemingly healthy individuals.
心血管疾病（CVD）仍然是全球死亡和残疾的主要原因。在沙特阿拉伯，心血管疾病的负担异常高，年龄标准化死亡率和患病率远远超过全球平均水平。当前的心血管疾病风险预测工具存在若干局限性，那些被归类为低至中度风险的人群仍会发生心血管事件，这凸显了通过有效的筛查和预防策略来应对心血管疾病的迫切需求。
一组沙特专家审查了关于使用高敏心肌肌钙蛋白（hs-cTn）来加强对看似健康个体的心血管风险评估的证据。根据文献和当地临床实践，考虑到沙特人群的特征、当地医疗系统、可用资源和医学专业知识，制定了适合沙特国情的共识性建议。
心肌肌钙蛋白是心肌损伤的生物标志物，使用高敏检测方法可在大多数看似健康的个体中检测到。研究表明，测量hs-cTn是一般人群未来心血管事件的可靠预测指标。因此，将hs-cTn纳入心血管风险评估可显著提高现有风险分层模型的准确性和有效性。专家们强调了这种方法相对于当前风险评估方法的额外益处。本文旨在指导将hs-cTn纳入对看似健康个体的心血管风险评估和预防策略中。
