Farrant Sarah, Giannaccare Giuseppe, Lim Chris Hong Long, Coco Giulia
Earlam and Christopher Optometrists Ltd, Taunton, UK.
Department of Surgical Sciences, Eye Clinic, University of Cagliari, Cagliari, Italy.
Clin Ophthalmol. 2025 Aug 7;19:2575-2585. doi: 10.2147/OPTH.S521989. eCollection 2025.
-associated blepharitis is a chronic disease of the lid accounting for over 60% of all blepharitis. Although several therapies have been employed to address mites' infestation, there is no universal consensus about the most effective strategy. Purpose of this study was to evaluate the efficacy of combined intense pulsed light (IPL) and low-level light therapy (LLLT) in the treatment of -associated blepharitis and associated ocular surface disease (OSD).
Medical records of patients with -associated blepharitis resistant to first-line therapy who underwent IPL and LLLT (12 minutes of blue light followed by 12 minutes of red light) were retrospectively examined. The following data collected before treatment (T0) and at last follow-up (T1) were reviewed: collarettes (0-4 grade); saponification (presence/absence); lid margin telangiectasia (0-3 grade); conjunctival hyperemia (0-4 grade); corneal fluorescein staining (CFS) (0-5 grade); noninvasive tear break-up time (NITBUT), tear meniscus height (TMH), inter-blink interval (IBI), meibomian gland dropout (0-3 grade) and symptoms (5-item Dry Eye Questionnaire [DEQ-5]). Treatment-related adverse effects (TrAEs) were recorded.
Data from 34 eyes of 17 patients (3 males, 14 females; mean age 64.6±10.0 years) were included. A mean of 7.6 ± 3.6 treatment sessions of IPL and LLLT was performed. Mean score of collarettes decreases significantly from 1.44 ± 0.83 at T0 to 1.00 ± 0.97 at T1 (p = 0.007). The rate of eyes with saponification decreases significantly (from 41.18% to 11.76%; p = 0.002). Conjunctival hyperemia significantly decreased from 2.00 ± 0.78 to 1.47 ± 0.61 (p = 0.005). Mean CFS score decreased significantly from 0.56 ± 1.16 to 0.24 ± 0.96 (p = 0.031). Symptoms' mean score improved significantly after treatment (from 12.00 ± 5.34 to 7.76 ± 4.92; p = 0.003). No patient reported TrAEs.
Combined light therapy with IPL and LLLT employing blue and red lights is an effective treatment strategy for patients with recalcitrant -associated blepharitis to reduce mites count and improve main ocular surface parameters along with patients' symptoms.
睑缘炎相关睑缘炎是一种眼睑慢性疾病，占所有睑缘炎的60%以上。尽管已采用多种疗法来应对螨虫感染，但对于最有效的策略尚无普遍共识。本研究的目的是评估强脉冲光（IPL）和低强度光疗法（LLLT）联合治疗睑缘炎相关睑缘炎及相关眼表疾病（OSD）的疗效。
回顾性检查了接受IPL和LLLT（12分钟蓝光后接12分钟红光）治疗的对一线治疗耐药的睑缘炎相关睑缘炎患者的病历。回顾了治疗前（T0）和最后一次随访（T1）收集的以下数据：鳞屑（0 - 4级）；皂化（存在/不存在）；睑缘毛细血管扩张（0 - 3级）；结膜充血（0 - 4级）；角膜荧光素染色（CFS）（0 - 5级）；无创泪膜破裂时间（NITBUT）、泪河高度（TMH）、眨眼间隔（IBI）、睑板腺缺失（0 - 3级）和症状（5项干眼问卷[DEQ - 5]）。记录与治疗相关的不良反应（TrAEs）。
纳入了17例患者（3例男性，14例女性；平均年龄64.6±10.0岁）的34只眼的数据。平均进行了7.6±3.6次IPL和LLLT治疗。鳞屑的平均评分从T0时的1.44±0.83显著降至T1时的1.00±0.97（p = 0.007）。有皂化的眼的比例显著降低（从41.18%降至11.76%；p = 0.002）。结膜充血从2.00±0.78显著降至1.47±0.61（p = 0.005）。平均CFS评分从0.56±1.16显著降至0.24±0.96（p = 0.031）。治疗后症状的平均评分显著改善（从12.00±5.34降至7.76±4.92；p = 0.003）。没有患者报告TrAEs。
采用蓝光和红光的IPL和LLLT联合光疗是治疗顽固性睑缘炎相关睑缘炎患者以减少螨虫数量、改善主要眼表参数及患者症状的有效治疗策略。
