Trattler William, Karpecki Paul, Rapoport Yuna, Sadri Ehsan, Schachter Scott, Whitley Walter O, Yeu Elizabeth
Center for Excellence in Eye Care, Miami, FL, USA.
Kentucky Eye Institute, Lexington, KY, USA.
Clin Ophthalmol. 2022 Apr 15;16:1153-1164. doi: 10.2147/OPTH.S354692. eCollection 2022.
To evaluate the prevalence of blepharitis by its pathognomonic sign, collarettes, in patients presenting for any reason to eye care clinics in the United States.
In this retrospective study by 7 investigators at 6 eye care clinics, case records of consecutive patients who underwent a slit-lamp examination, regardless of chief complaint, were reviewed for blepharitis, as identified by the presence of collarettes. Patient characteristics, including age, gender, race, relevant ocular and systemic diagnoses, ocular medications, lid hygiene practices and contact lens wear, were also recorded.
Of 1032 patients (mean age: 60.2 ± 17.8 years), 57.7% had blepharitis. While the prevalence of blepharitis in patients with dry eye disease (DED) (58.9%) and cataract (55.7%) was similar to the overall prevalence of blepharitis, it was higher in patients with blepharitis (69.1%) and glaucoma (64.8%). Among patients with collarettes, 44.0% had never been diagnosed with blepharitis. Among those on anti-inflammatory DED treatment, 60.0% had blepharitis. blepharitis prevalence was significantly higher among those using topical tea tree oil versus those who were not (74.5% versus 56.7% p = 0.014); prevalence was comparable among those using/not using lid wipes (56.9% versus 55.5%).
blepharitis, based on the pathognomonic finding of collarettes, is common and likely underdiagnosed among patients seeking eye care. These collarettes are still found in patients using over-the-counter treatments for blepharitis. The present study highlights the importance of screening patients for collarettes and blepharitis as part of every slit-lamp examination.
通过睑缘炎的特征性体征——睑缘小结,评估在美国因任何原因前往眼科诊所就诊的患者中睑缘炎的患病率。
在这项由6家眼科诊所的7名研究人员开展的回顾性研究中,对连续接受裂隙灯检查的患者的病历进行审查,不论其主要诉求如何,通过睑缘小结的存在来确定是否患有睑缘炎。还记录了患者的特征,包括年龄、性别、种族、相关的眼部和全身诊断、眼部用药、眼睑卫生习惯以及隐形眼镜佩戴情况。
在1032例患者(平均年龄:60.2±17.8岁)中,57.7%患有睑缘炎。虽然干眼症(DED)患者(58.9%)和白内障患者(55.7%)中睑缘炎的患病率与睑缘炎的总体患病率相似,但睑板腺功能障碍患者(69.1%)和青光眼患者(64.8%)中的患病率更高。在有睑缘小结的患者中,44.0%从未被诊断出患有睑缘炎。在接受抗炎性DED治疗的患者中,60.0%患有睑缘炎。使用局部茶树油的患者中睑缘炎患病率显著高于未使用者(74.5%对56.7%,p = 0.014);使用/未使用眼睑擦拭物的患者中患病率相当(56.9%对55.5%)。
基于睑缘小结这一特征性表现,睑缘炎在寻求眼科护理的患者中很常见且可能未被充分诊断。在使用非处方睑缘炎治疗的患者中仍可发现这些睑缘小结。本研究强调了在每次裂隙灯检查时对患者进行睑缘小结和睑缘炎筛查的重要性。