Storm F K, Christensen D A, Olch A J, Silberman A W, Roe D J, Harrison W H, Elliott R S, Morton D L
J Surg Oncol. 1985 Jun;29(2):82-8. doi: 10.1002/jso.2930290204.
In a test of electromagnetic induction hyperthermia to deep viscera of a live dog model, we found that heating was not uniform to any depth, but was quite variable. In general, there was a thermal gradient between peripheral and central portions of the transposed spleen of about 1 degree C. Though heat generation within the abdomen was not uniform, its temperature pattern in the alive animal resulted in significant heating of that part of the organ that had been surgically placed at the center of the animal. This heating could not be explained by perfusion with regionally heated core blood. Our results indicate that extensive investigations in living systems and complex dynamic phantoms will be necessary before individual patient response can be predicted.
在对一只活犬模型的深部脏器进行电磁感应热疗测试时，我们发现，在任何深度加热都不均匀，而是变化很大。一般来说，移位脾脏的外周和中央部分之间存在约1摄氏度的热梯度。虽然腹部内的产热不均匀，但其在活体动物中的温度模式导致手术放置在动物中心部位的器官部分出现显著升温。这种升温无法用局部加热的核心血液灌注来解释。我们的结果表明，在能够预测个体患者的反应之前，有必要在活体系统和复杂动态模型中进行广泛研究。
