Storm F K, Harrison W H, Elliott R S, Silberman A W, Morton D L
Int J Radiat Oncol Biol Phys. 1982 May;8(5):865-71. doi: 10.1016/0360-3016(82)90090-6.
Hyperthermia has shown promise for the treatment of cancer. The magnetrode radio-frequency magnetic-loop induction applicator was recently introduced and is being evaluated at many centers with encouraging initial results. This investigation was undertaken to delineate the thermal distribution patterns of magnetrode hyperthermia in both normal tissue phantoms and healthy dogs. Temperatures on homogeneous and heterogeneous tissue equivalents and animal tissue phantoms, a dead animal extremity, a dead dog and a live dog subjected to rapid high-dose heating showed preferential and potentially injurious peripheral heating with a central "cold spot." However, sequential moderate-dose heating in live dogs showed virtually uniform (less than 1 degree C) and potentially tumoricidal temperatures greater than or equal to 42 degrees C in both peripheral and central internal organs without injury to surface tissues. These data indicate that magnetic-loop induction can produce potentially safe and effective deep central heat in living, normal animals, but that safety and effectiveness are significantly influenced by the velocity of heat deposition. Furthermore, normal tissue phantom models and dead animals are unreliable predictors of magnetrode heat patterns in living systems.
热疗已显示出治疗癌症的前景。磁电极射频磁环感应热疗仪最近被引入，并正在多个中心进行评估，初步结果令人鼓舞。本研究旨在描绘磁电极热疗在正常组织模型和健康犬体内的热分布模式。在均匀和非均匀组织等效物、动物组织模型、死动物肢体、死犬和接受快速高剂量加热的活犬上进行的温度测量显示，存在优先且可能有害的外周加热以及中央“冷点”。然而，对活犬进行的序贯中等剂量加热显示，外周和中央内部器官的温度几乎均匀（小于1摄氏度）且可能具有杀肿瘤作用，温度大于或等于42摄氏度，同时表面组织未受损伤。这些数据表明，磁环感应可在活体正常动物体内产生潜在安全有效的深部中央热，但安全性和有效性受热沉积速度的显著影响。此外，正常组织模型和死动物并不能可靠地预测磁电极在活体系统中的热模式。
