Byun Garam, Kim Sera, Festa Natalia, Choi Yongsoo, Lee Woong-Woo, Lee Jong-Tae, Gill Thomas M, Bell Michelle L
School of the Environment, Yale University, New Haven, CT, United States.
Multidisciplinary Research Center for Public Health in Complex System, Korea University, Seoul, Republic of Korea.
Int J Epidemiol. 2025 Jun 11;54(4). doi: 10.1093/ije/dyaf142.
Dementia is a growing health problem as the global population ages. However, the research on the effects of ambient temperatures on various health outcomes among people with dementia remains limited. This study examined the association between daily temperatures and hospital admissions for dementia among older adults with dementia, as well as their association with all-cause hospital admissions and mortality among individuals with and without dementia.
This study utilized the National Health Insurance Service-Senior Cohort from 2002 to 2019, consisting of approximately one million older adults in South Korea. Individuals with dementia were identified based on medical claims. Daily mean temperatures were obtained from national monitoring stations and averaged at the province level. We employed a time-stratified case-crossover design to estimate the association between daily temperatures and the risk of hospital admissions and mortality.
In the total cohort of 1 057 784 individuals, 78 424 were identified as having dementia. The association between temperature and dementia admissions showed a hockey stick-shaped curve, indicating an elevated risk at higher temperatures. The relative risk (RR) for dementia admissions at the 99th percentile temperature compared to the 50th percentile temperature was 1.36 (95% confidence interval: 1.19-1.57). Individuals with dementia showed more pronounced increases in all-cause hospital admissions and mortality at high temperatures compared to those without dementia.
Our study found that high temperatures increased the risk of hospital admissions for dementia in older adults with dementia. Additionally, those with dementia may experience greater health impacts from extreme temperatures than those without, due to physiological and behavioral vulnerabilities.
随着全球人口老龄化,痴呆症成为一个日益严重的健康问题。然而,关于环境温度对痴呆症患者各种健康结局影响的研究仍然有限。本研究调查了日温度与老年痴呆症患者痴呆症住院率之间的关联,以及它们与有无痴呆症个体的全因住院率和死亡率之间的关联。
本研究利用了2002年至2019年的国民健康保险服务老年队列,该队列由韩国约100万老年人组成。根据医疗理赔记录确定痴呆症患者。日平均温度从国家监测站获取,并在省级层面进行平均。我们采用时间分层病例交叉设计来估计日温度与住院率和死亡率风险之间的关联。
在总共1057784名个体的队列中,有78424人被确定患有痴呆症。温度与痴呆症住院之间的关联呈曲棍球棒状曲线,表明在较高温度下风险升高。与第50百分位数温度相比,第99百分位数温度下痴呆症住院的相对风险(RR)为1.36(95%置信区间:1.19 - 1.57)。与没有痴呆症的个体相比,痴呆症患者在高温下全因住院率和死亡率增加更为明显。
我们的研究发现,高温增加了老年痴呆症患者痴呆症住院的风险。此外,由于生理和行为方面的脆弱性,痴呆症患者可能比非痴呆症患者更容易受到极端温度的健康影响。