The George Institute for Global Health, University of New South Wales, Sydney, Australia.
Centre on Climate Change and Planetary Health, London School of Hygiene & Tropical Medicine, London, UK.
Environ Int. 2022 Jan 15;159:107027. doi: 10.1016/j.envint.2021.107027. Epub 2021 Dec 7.
The impacts of a changing climate on current and future dementia burdens have not been widely explored.
Time-series negative binomial regression analysis was used to assess acute associations between daily ambient temperature and counts of emergency admissions for dementia in each Government region of England, adjusting for season and day-of-week. Using the latest climate and dementia projections data, we then estimate future heat-related dementia burdens under a high emission scenario (Representative Concentration Pathway (RCP8.5), where global greenhouse gas (GHG) emissions continue to rise, and a low emissions scenario (RCP2.6), where GHG emissions are sizeably reduced under a strong global mitigation policy.
A raised risk associated with high temperatures was observed in all regions. Nationally, a 4.5% (95% Confidence interval (CI) 2.9%-6.1%) increase in risk of dementia admission was observed for every 1 °C increase in temperature above 17 °C associated with current climate. Under a high emissions scenario, heat-related admissions are projected to increase by almost 300% by 2040 compared to baseline levels.
People living with dementia should be considered a high-risk group during hot weather. Our results support arguments for more stringent climate change mitigation policies.
气候变化对当前和未来痴呆症负担的影响尚未得到广泛探讨。
采用时间序列负二项回归分析,调整季节和星期几的影响,评估英格兰各政府区域每日环境温度与痴呆症急诊入院人数之间的急性关联。然后,我们使用最新的气候和痴呆症预测数据,在高排放情景(代表浓度途径(RCP8.5)下,全球温室气体(GHG)排放继续上升,以及低排放情景(RCP2.6)下,在强有力的全球缓解政策下,GHG 排放大幅减少)下估计未来与热相关的痴呆症负担。
在所有地区都观察到与高温相关的风险增加。在全国范围内,与当前气候相比,温度每升高 1°C 超过 17°C,痴呆症入院风险增加 4.5%(95%置信区间(CI)2.9%-6.1%)。在高排放情景下,与基线水平相比,到 2040 年,与热相关的入院人数预计将增加近 300%。
患有痴呆症的人在炎热天气下应被视为高风险人群。我们的研究结果支持采取更严格的气候变化缓解政策的论点。