Heidari Nia Marzieh, Heidari Nia Shahrzad, Munguia-Lopez Jose G, Ashkar Said, Kinsella Joseph M, Wilson Lee D, van de Ven Theo G M
Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada; Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC H3A 0B8, Canada; Quebec Centre for Advanced Materials (QCAM) and Pulp and Paper Research Centre, McGill University, 3420 University Street, Montreal, QC H3A 2A7, Canada.
Department of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
J Colloid Interface Sci. 2025 Dec 15;700(Pt 3):138627. doi: 10.1016/j.jcis.2025.138627. Epub 2025 Aug 6.
Nanomaterial-based delivery systems have gained significant attention for their ability to provide high surface area, tunable porosity, and tailored surface chemistry, key features that enable efficient adsorption and controlled release of active agents. These advanced platforms offer versatile solutions for applications ranging from therapeutic delivery to environmental remediation, by improving loading capacity, release kinetics, and functional performance. Here we tailor a novel core-shell silica nanomaterial with a large complex internal structure in the core and shell, while silica surfaces are bridged by an organic crosslinker in the shell. Firstly, the organo-silica bridging agent (bivalent organic crosslinkers) DABCO-S was prepared through a simple nucleophilic substitution reaction between 3-chloropropyl-triethoxysilane and a strong base bivalent 1,4-diazabicyclo[2.2.2]octane (DABCO). Secondly, dendritic fibrous nanostructured silica (DFNS) was synthesized as the core nanostructure. Thirdly, DABCO-S bridges were integrated into the DFNS morphology surrounding the DFNS core under open-vessel reflux conditions. The resulting core-shell product, incorporating the DABCO-S bridges within the silica shell network around DFNS, is referred to as the DDC structure. This design was strategically chosen based on the hypothesis that such colloidal systems would serve as highly efficient adsorbents for sparsely soluble drug compounds. The pH-responsive DDC colloidal hybrid carriers were evaluated as biocompatible carriers for controlled doxorubicin (DOX) delivery. The results demonstrated that cancer cells exhibited lower viability when treated with DOX-loaded DDC colloidal hybrid carriers compared to free DOX or control groups, indicating an enhanced anticancer effect of the loaded carrier. The high drug loading capacity, encapsulation efficiency, and pH-responsive behavior of these colloidal hybrid carriers in varying cellular environments confirm their suitability as promising candidates for further studies. Future research could focus on incorporating targeting functionalities to enhance their potential as active drug delivery systems.
基于纳米材料的递送系统因其具有高比表面积、可调节的孔隙率和定制的表面化学性质而备受关注，这些关键特性能够实现活性剂的高效吸附和控释。通过提高负载能力、释放动力学和功能性能，这些先进平台为从治疗性递送环境修复等广泛应用提供了多功能解决方案。在这里，我们定制了一种新型核壳二氧化硅纳米材料，其核和壳具有大型复杂内部结构，而二氧化硅表面在壳中由有机交联剂桥接。首先，通过3-氯丙基三乙氧基硅烷与强碱二价1,4-二氮杂双环[2.2.2]辛烷（DABCO）之间的简单亲核取代反应制备有机硅桥联剂（二价有机交联剂）DABCO-S。其次，合成树枝状纤维纳米结构二氧化硅（DFNS）作为核心纳米结构。第三，在开放容器回流条件下，将DABCO-S桥整合到围绕DFNS核心的DFNS形态中。所得的核壳产物，在DFNS周围的二氧化硅壳网络中包含DABCO-S桥，被称为DDC结构。这种设计是基于这样的假设战略选择的，即这种胶体系统将作为难溶性药物化合物的高效吸附剂。对pH响应性DDC胶体杂化载体作为用于阿霉素（DOX）控释的生物相容性载体进行了评估。结果表明，与游离DOX或对照组相比，用负载DOX的DDC胶体杂化载体处理时癌细胞的活力较低，表明负载载体的抗癌效果增强。这些胶体杂化载体在不同细胞环境中的高药物负载能力、包封效率和pH响应行为证实了它们作为进一步研究的有前途候选者的适用性。未来的研究可以集中在引入靶向功能，以增强它们作为活性药物递送系统的潜力。
