Haykal D, Benhamou A-C, Lotti T, Duteille F
Centre Laser Palaiseau, Private Practice, Palaiseau, France.
Paris Sorbonne University, Paris, France.
Ann Chir Plast Esthet. 2025 Aug 11. doi: 10.1016/j.anplas.2025.06.013.
3D skin bioprinting is a transformative innovation in regenerative medicine, offering new possibilities for wound healing, reconstructive surgery, and disease modeling. By enabling the precise fabrication of patient-specific skin grafts, this technology addresses critical medical challenges, including severe burns, chronic ulcers, traumatic injuries, and genetic skin disorders. Advances in bioprinting techniques, bioink formulations, and vascularization strategies have enhanced graft integration and functional restoration, avoiding immune rejection risks. Beyond transplantation, 3D skin models provide a powerful platform for dermatological research, pharmacological testing, and tissue engineering, accelerating drug discovery while minimizing reliance on animal testing. Additionally, 3D bioprinting is revolutionizing cosmetic and reconstructive dermatology, enabling personalized aesthetic procedures, scar treatments, and anti-aging interventions that complement clinical applications. The future of 3D skin bioprinting lies in multi-tissue fabrication, AI-assisted biofabrication, and immunomodulatory grafts, which could revolutionize personalized medicine and regenerative healthcare. Despite ongoing challenges in clinical scalability and regulatory pathways, continued interdisciplinary research is driving the field closer to real-world medical applications. This review provides a structured timeline of advancements, compares bioprinting techniques, and offers specific examples of clinical and commercial applications. It concludes with a discussion of future directions, emphasizing sustainable bioinks, AI-assisted fabrication, and ethical frameworks.
3D皮肤生物打印是再生医学领域的一项变革性创新，为伤口愈合、整形手术和疾病建模提供了新的可能性。通过能够精确制造患者特异性皮肤移植物，这项技术解决了包括严重烧伤、慢性溃疡、创伤性损伤和遗传性皮肤病在内的关键医学挑战。生物打印技术、生物墨水配方和血管化策略的进步增强了移植物的整合和功能恢复，避免了免疫排斥风险。除了移植，3D皮肤模型为皮肤病学研究、药理学测试和组织工程提供了一个强大的平台，加速了药物发现，同时最大限度地减少了对动物测试的依赖。此外，3D生物打印正在彻底改变美容和整形皮肤科，实现个性化美容手术、疤痕治疗和抗衰老干预，以补充临床应用。3D皮肤生物打印的未来在于多组织制造、人工智能辅助生物制造和免疫调节移植物，这可能会彻底改变个性化医疗和再生医疗保健。尽管在临床可扩展性和监管途径方面仍存在挑战，但持续的跨学科研究正在推动该领域更接近实际医疗应用。这篇综述提供了一个结构化的进展时间表，比较了生物打印技术，并提供了临床和商业应用的具体例子。它最后讨论了未来的方向，强调了可持续生物墨水、人工智能辅助制造和伦理框架。
