Gormley Maurade, Lawrence Wayne R, Plascak Jesse J, Paskett Electra D, Omene Coral, Llanos Adana A M
School of Nursing, University of Connecticut, Storrs, CT, USA.
Department of Epidemiology and Biostatistics, University at Albany, State University of New York, Rensselaer, NY, USA.
NPJ Breast Cancer. 2025 Aug 13;11(1):90. doi: 10.1038/s41523-025-00812-0.
Despite advances in detection and treatment, Black women in the US continue to experience more aggressive breast cancer subtypes and higher mortality. Framed through a Society-to-Cells lens, this review presents a comprehensive framework for understanding how multilevel drivers-from structural forces to cellular responses-interact to perpetuate disparities. Addressing these inequities requires systemic reforms targeting root causes, including policies to redress historical neighborhood disinvestment and eliminate bias within healthcare systems.
尽管在检测和治疗方面取得了进展，但美国黑人女性仍继续面临更具侵袭性的乳腺癌亚型，死亡率也更高。本综述从社会层面到细胞层面的视角出发，提出了一个全面的框架，以理解从结构力量到细胞反应的多层次驱动因素如何相互作用，使差异长期存在。解决这些不平等问题需要针对根本原因进行系统性改革，包括纠正历史上社区投资不足的政策以及消除医疗系统内的偏见。
