酒精性肝病患者中的乙肝病毒抗原和抗体。乙肝病毒在酒精性肝病患者肝脏疾病中的病因学作用。

Hepatitis B virus antigen and antibodies in alcoholics. Etiological role of HBV in liver diseases of alcoholic patients.

作者信息

Inoue K, Kojima T, Koyata H, Matsui S, Aoyama K, Konda T, Ichida T, Sasaki H

出版信息

Liver. 1985 Oct;5(5):247-52. doi: 10.1111/j.1600-0676.1985.tb00245.x.

DOI:10.1111/j.1600-0676.1985.tb00245.x

Abstract

A study was carried out to clarify the pathogenetic role of HBV in alcoholic patients with liver diseases. The incidence of serological markers of HBV infection was investigated in these patients and the histological characteristics were compared among the alcoholic patients with and without HBV markers. A high percentage of patients were positive for either HBsAg, anti-HBs or anti-HBc. In six of eight patients with positive HBsAg, liver histology showed viral features, but in 23 of 39 patients with positive anti-HBs and/or low titre anti-HBc and in 12 of 18 patients with negative HBV markers liver histology showed alcoholic features. From these results it is concluded that HBV presumably plays a major role in the pathogenesis of liver disease in alcoholic patients with persistent HBV infection but not in patients with positive antibodies.

摘要

开展了一项研究以阐明乙肝病毒（HBV）在酒精性肝病患者发病机制中的作用。对这些患者中HBV感染血清学标志物的发生率进行了调查，并比较了有和没有HBV标志物的酒精性患者的组织学特征。高比例患者的乙肝表面抗原（HBsAg）、乙肝表面抗体（抗-HBs）或乙肝核心抗体（抗-HBc）呈阳性。在8例HBsAg阳性患者中的6例，肝脏组织学显示病毒特征，但在39例抗-HBs阳性和/或低滴度抗-HBc阳性患者中的23例，以及18例HBV标志物阴性患者中的12例，肝脏组织学显示酒精性特征。从这些结果得出结论，HBV可能在持续HBV感染的酒精性肝病患者的发病机制中起主要作用，但在抗体阳性患者中并非如此。