哺乳动物神经丝蛋白中的结构同源性。

Sturctural homologies in mammalian neurofilament proteins.

作者信息

Davison P F, Hong B S

出版信息

Brain Res. 1977 Oct 7;134(2):287-95. doi: 10.1016/0006-8993(77)91074-5.

Abstract

Antibody has been prepared to purified neurofilament protein extracted from calf brain. This antibody crossreacts with brain and nerve extracts from all mammals tested but fails to crossreact with frog, cod and chicken nerve extracts. Thus the serologic homology of these neurofilament proteins appears to be restricted to the mammals. Structural similarities between the mammalian neurofilament protein are also indicated by the strong resemblance between iodinated peptide maps prepared from the electrophoretically purified neurofilament proteins.

摘要

已制备出针对从小牛脑提取的纯化神经丝蛋白的抗体。该抗体与所有测试的哺乳动物的脑和神经提取物发生交叉反应，但与青蛙、鳕鱼和鸡的神经提取物不发生交叉反应。因此，这些神经丝蛋白的血清学同源性似乎仅限于哺乳动物。从电泳纯化的神经丝蛋白制备的碘化肽图之间的强烈相似性也表明了哺乳动物神经丝蛋白之间的结构相似性。