Movahedian Attar Fakhereh, Kirilina Evgeniya, Chaimow Denis, Haenelt Daniel, Schneider Christian, Edwards Luke J, Pine Kerrin J, Jäger Carsten, Reimann Katja, Pohlmann Andreas, Periquito João, Streubel Tobias, Trampel Robert, Mohammadi Siawoosh, Niendorf Thoralf, Morawski Markus, Weiskopf Nikolaus
Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Institute for Anatomy I, Medical Faculty & University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Imaging Neurosci (Camb). 2025 Mar 10;3. doi: 10.1162/imag_a_00498. eCollection 2025.
Despite the importance of short association fibres (SAF) for human brain function, their structures remain understudied. It is not known how SAF are organised across the brain, and how consistent their geometries and locations are across individuals. To address this gap, we mapped the precise structures of SAF in the primary (V1) and secondary (V2) visual cortex in a group of participantsand aspecimen. We assessed the consistency of SAF geometries and their expected structural and functional topography using probabilistic tractography on sub-millimetre-resolution diffusion-weighted MRI combined with functional MRI retinotopic maps. We found that dense SAF connected V1 and V2, forming sheet structures with retinotopic topography and bearing consistent geometries that resembled the local V1-V2 cortical folding.findings were corroborated by the robust and fine-grainedreference. Ourapproach provides important insights into SAF organisation and could be applied to studies across species on cortical and SAF reorganisation and support neuronavigation.
尽管短联合纤维（SAF）对人类大脑功能很重要，但其结构仍未得到充分研究。目前尚不清楚SAF在整个大脑中是如何组织的，以及它们的几何形状和位置在个体之间的一致性如何。为了填补这一空白，我们绘制了一组参与者和一个标本的初级（V1）和次级（V2）视觉皮层中SAF的精确结构。我们使用亚毫米分辨率扩散加权MRI结合功能MRI视网膜拓扑图的概率纤维束成像，评估了SAF几何形状的一致性及其预期的结构和功能拓扑。我们发现密集的SAF连接V1和V2，形成具有视网膜拓扑的片状结构，并具有与局部V1-V2皮质折叠相似的一致几何形状。我们的发现得到了可靠且精细的参考的证实。我们的方法为SAF组织提供了重要见解，可应用于跨物种的皮质和SAF重组研究以及支持神经导航。
