Chen Xinbei, Wu Lijuan, Zheng Yan, Ni Xuling, Zhuang Xiaojin, Chen Liming, Hu Qiaoling, Zou Chunyan, Yin Lianhua
Health Management Center, The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.
Front Endocrinol (Lausanne). 2025 Jul 29;16:1614149. doi: 10.3389/fendo.2025.1614149. eCollection 2025.
The aim of this study is to compare the effectiveness of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on body composition, cardiovascular function, glycolipid metabolism, and cardiopulmonary function in patients with pre-diabetes.
Seventy-one participants were randomly assigned to the HIIT (10 × 1-min at 75%-90% HR, intersperse with 1-min active recovery at 50% HR) or MICT (50 min at 55%-70% HR) for a 12-week (three times per week) program. The outcome measured was the change in body composition, cardiovascular index, glycolipid metabolism, and cardiopulmonary. The trial was registered on the Clinical Trial Registry (ChiCTR1900026905).
The body mass index decreased in the HIIT ( = 0.016) and MICT ( = 0.021) groups. The participants in the MICT group had a significantly decreased in visceral adipose area ( = 0.043) and body fat rate ( = 0.030) after training, compared with the HIIT group. Analysis of systolic blood pressure revealed statistical difference in the HIIT and MICT interventions ( < 0.001), but there was not statistical difference between groups ( = 0.398). MICT was better than HIIT in reducing diastolic blood pressure ( = 0.011). The significant effect of fasting blood glucose, 2-h glucose, and glycated hemoglobin (HbA1c) showed an obvious descent in the HIIT and MICT groups ( < 0.001). Regarding the blood lipid, triglyceride decreased significantly more in the MICT group than that in the HIIT group ( = 0.006). VO increased in both the HIIT and MICT groups, but there was no significant between-group difference ( = 0.647).
HIIT and MICT significantly improved blood glucose and aerobic capacity in patients with pre-diabetes. However, MICT was superior to HIIT in terms of visceral fat, lipids, and diastolic blood pressure.
https://www.chictr.org.cn/, identifier ChiCTR1900026905.
本研究旨在比较高强度间歇训练（HIIT）和中等强度持续训练（MICT）对糖尿病前期患者身体成分、心血管功能、糖脂代谢和心肺功能的影响。
71名参与者被随机分配到HIIT组（75%-90%心率下进行10次1分钟训练，穿插50%心率下1分钟的主动恢复）或MICT组（55%-70%心率下进行50分钟训练），为期12周（每周三次）。测量的结果是身体成分、心血管指数、糖脂代谢和心肺功能的变化。该试验已在临床试验注册中心注册（ChiCTR1900026905）。
HIIT组（P = 0.016）和MICT组（P = 0.021）的体重指数均下降。与HIIT组相比，MICT组参与者训练后内脏脂肪面积（P = 0.043）和体脂率（P = 0.030）显著降低。收缩压分析显示HIIT和MICT干预存在统计学差异（P < 0.001），但组间无统计学差异（P = 0.398）。MICT在降低舒张压方面优于HIIT（P = 0.011）。空腹血糖、餐后2小时血糖和糖化血红蛋白（HbA1c）的显著效果显示HIIT组和MICT组均明显下降（P < 0.001）。关于血脂，MICT组甘油三酯下降幅度明显大于HIIT组（P = 0.006）。HIIT组和MICT组的VO均增加，但组间无显著差异（P = 0.647）。
HIIT和MICT均能显著改善糖尿病前期患者的血糖和有氧能力。然而，在减少内脏脂肪、血脂和舒张压方面，MICT优于HIIT。
