Campanella Salvatore, Dubuson Macha, Pereira Maylis, Mouras Harold, Leonard Guillaume, Noel Xavier, Lelard Thierry
Laboratoire de Psychologie Médicale et d'Addictologie, ULB Neuroscience Institute (UNI), CHU Brugmann-Université Libre de Bruxelles (U.L.B.), Belgium.
UR-UPJV: LNFP, Laboratoire de Neurosciences Fonctionnelles et Pathologies, Centre Universitaire de Recherche en Santé, rue René-Laennec, Amiens cedex, France.
PLoS One. 2025 Aug 13;20(8):e0327765. doi: 10.1371/journal.pone.0327765. eCollection 2025.
This exploratory study investigates approach/avoidance tendencies in male patients with Alcohol Use Disorder (AUD) through a gait initiation task combined with posturography.
Seventy-four male participants (N = 74), including 47 AUD patients undergoing detoxification and 27 healthy controls, were exposed to alcohol-related, erotic, and neutral visual stimuli. Reaction times (RTs) and postural micromovements preceding gait initiation (forward/backward steps) were recorded to assess their predictive value for relapse (n = 13) or abstinence (n = 34) within two weeks post-detoxification.
A mixed ANOVA (2x2x3) revealed significant group differences in RTs to alcohol-related stimuli (Stimuli × Group interaction: p = .029), with relapsers showing slower responses to alcohol cues than abstainers for forward as well as backward steps. Additionally, postural micromovements before gait initiation (measured through the standard deviation of the center of pressure's position) showed a significant Stimuli × Group interaction (p = 0.05), with relapsers displaying increased micromovements when exposed to alcohol-related stimuli (p = .044).
These findings suggest that relapsers exhibited distinct motor responses to alcohol-related stimuli, characterized by delayed RTs and increased postural instability. These early indicators of relapse risk highlight the potential of posturography as a clinical tool in alcohol detoxification programs.
本探索性研究通过步态启动任务结合姿势描记法，调查酒精使用障碍（AUD）男性患者的趋近/回避倾向。
74名男性参与者（N = 74），包括47名正在接受脱毒治疗的AUD患者和27名健康对照者，暴露于与酒精相关、色情和中性的视觉刺激下。记录步态启动（向前/向后步）前的反应时间（RTs）和姿势微运动，以评估它们对脱毒后两周内复发（n = 13）或戒酒（n = 34）的预测价值。
混合方差分析（2x2x3）显示，对与酒精相关刺激的反应时间存在显著的组间差异（刺激×组交互作用：p = 0.029），复发者对酒精线索的反应在向前和向后步方面均比戒酒者慢。此外，步态启动前的姿势微运动（通过压力中心位置的标准差测量）显示出显著的刺激×组交互作用（p = 0.05），复发者在暴露于与酒精相关刺激时微运动增加（p = 0.044）。
这些发现表明，复发者对与酒精相关刺激表现出独特的运动反应，其特征为反应时间延迟和姿势不稳定性增加。这些复发风险的早期指标凸显了姿势描记法作为酒精脱毒计划临床工具的潜力。
