Boakye Andrews, Bushira Fuad Abduro, Houston Lystra Sarah, Zhong Geng, Chen Litong, Zou Faxing, Xu Tailin, Zhang Xueji
School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, China.
Key Laboratory of Marine Drugs of Ministry of Education, Shandong Key Laboratory of Glycoscience and Glycotechnology, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
ACS Appl Mater Interfaces. 2025 Aug 27;17(34):48123-48133. doi: 10.1021/acsami.5c13392. Epub 2025 Aug 13.
Wearable sweat biosensors engineered for continuous measurement and real-time analysis of diverse health-related biomarkers have garnered considerable interest in recent years. Their excellent sensitivity, noninvasiveness, and point-of-care monitoring capabilities make them extremely desirable. Here, we report a wearable sweat sensor patch based on a composite of gold nanoparticles (AuNPs) modified Copper MOF (Cu-MOF)-derived electrospun carbon nanofibers (CNFs) for the individual and simultaneous detection of uric acid (UA), tyrosine (Tyr), and other metabolites. The inherent properties of the Cu-MOF, including large surface area, tunable porosity, and accessible active sites, combined with the improved electron transfer and favorable electrical conductivity conferred by the AuNPs, rendered the Au@Cu-MOF material an exceptional electrocatalyst for the redox reactions of target biomarkers. The electrospun mesoporous carbon nanofibers enhanced the electrical conductivity and wettability of the composite, allowing it to function effectively as a working electrode in an electrochemical sensor system. Finally, we designed and validated a wearable sweat biosensor patch that detects sweat UA and Tyr in real-time using Au@Cu-MOF/PAN-CNF composite. The biosensor incorporates a lightweight circuit board that supports wireless transmission, making it a portable and convenient device for the continuous monitoring of human metabolism. Experimental results indicate that the sensor has the potential to be a next-generation wearable sweat sensor, exhibiting outstanding selectivity and reproducibility.
近年来，为连续测量和实时分析多种与健康相关的生物标志物而设计的可穿戴汗液生物传感器引起了广泛关注。它们出色的灵敏度、非侵入性和即时监测能力使其极具吸引力。在此，我们报道了一种基于金纳米颗粒（AuNPs）修饰的铜金属有机框架（Cu-MOF）衍生的电纺碳纳米纤维（CNFs）复合材料的可穿戴汗液传感器贴片，用于单独和同时检测尿酸（UA）、酪氨酸（Tyr）及其他代谢物。Cu-MOF的固有特性，包括大表面积、可调孔隙率和可及的活性位点，与AuNPs赋予的改善的电子转移和良好的导电性相结合，使Au@Cu-MOF材料成为用于目标生物标志物氧化还原反应的优异电催化剂。电纺介孔碳纳米纤维增强了复合材料的导电性和润湿性，使其能够在电化学传感器系统中有效地作为工作电极发挥作用。最后，我们设计并验证了一种可穿戴汗液生物传感器贴片，该贴片使用Au@Cu-MOF/PAN-CNF复合材料实时检测汗液中的UA和Tyr。该生物传感器集成了一个支持无线传输的轻质电路板，使其成为用于连续监测人体代谢的便携式便捷设备。实验结果表明，该传感器有潜力成为下一代可穿戴汗液传感器，具有出色的选择性和重现性。
