Department of Mental Health, Department of Biomedical and Clinical Sciences Luigi Sacco, University of Milan, 20122 Milan, Italy.
"Aldo Ravelli" Center for Neurotechnology and Brain Therapeutic, University of Milan, 20122 Milan, Italy.
Int J Environ Res Public Health. 2023 Jan 21;20(3):1994. doi: 10.3390/ijerph20031994.
Poor adherence to treatment is currently stated to be one of the causes of depression relapse and recurrence. The aim of the present study is to assess potential differences in terms of clinical and lifestyle features related to adherence to treatment in a sample of patients with unipolar and bipolar depression. One hundred and eight patients with a diagnosis of unipolar or bipolar depressive episode were recruited from January 2021 to October 2022. Adherence to psychopharmacological treatment was assessed using the clinician rating scale. Descriptive and association analyses were performed to compare subgroups based on adherence to treatment. Lower levels of adherence to treatment were associated with fewer years of education, work impairment, manic prevalent polarity lifetime, and greater comorbidity with alcohol and drug abuse. The majority of patients with positive adherence did not report any hospitalization and involuntary commitment lifetime. Patients with a positive treatment adherence showed significant differences in terms of lifestyle and clinical features compared to non-adherent patients. Our results may help to identify patients more likely to have poor medication adherence, which seem to lead to a worse disease course and quality of life.
目前认为，治疗依从性差是导致抑郁症复发和再发的原因之一。本研究旨在评估单相和双相抑郁症患者样本中与治疗依从性相关的临床和生活方式特征方面的潜在差异。
从 2021 年 1 月至 2022 年 10 月，共招募了 108 名单相或双相抑郁发作的患者。使用临床医生评定量表评估抗精神病药物治疗的依从性。根据治疗依从性进行描述性和关联分析，以比较亚组。
治疗依从性较低与受教育年限较少、工作受损、躁狂发作时的普遍极性以及与酒精和药物滥用的共病率较高有关。大多数依从性良好的患者报告没有住院治疗和非自愿住院治疗。
与不依从的患者相比，治疗依从性良好的患者在生活方式和临床特征方面存在显著差异。我们的结果可能有助于识别更有可能出现药物依从性差的患者，这似乎会导致更差的疾病进程和生活质量。
