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德国抑郁症的数字健康应用:证据的叙述性综述及纳入治疗

[Digital health applications for depressive disorders in Germany : A narrative review of the evidence and integration into treatment].

作者信息

Kaminski Jakob, Machleid Felix, Wiegmann Caspar, Klein Jan Philipp, Rakitzis Orestis, Haaf Raoul, Schreiter Stefanie, Preiß Maximilian, Pezawas Lukas, Titzler Ingrid

机构信息

Department of Psychiatry and Neurosciences, Charité Campus Mitte, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Deutschland.

Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Deutschland.

出版信息

Nervenarzt. 2025 Aug 13. doi: 10.1007/s00115-025-01879-7.

Abstract

BACKGROUND

Digital technologies open up new opportunities in the treatment of mental health disorders. Internet-based and mobile telephone-based interventions (IMIs), in particular, have proven to be effective, cost-efficient and accessible approaches to improving the care of people with mental disorders. In Germany digital health applications (DiGAs) that are reimbursed by all public health insurances are gaining increasing importance in routine clinical practice.

OBJECTIVE

This article provides a narrative review of the evidence and challenges related to DiGAs for depression in the German healthcare system. The approved DiGAs are presented and key studies, developments and perspectives for future research and care concepts are discussed.

MATERIAL AND METHODS

This study is based on a narrative review of the relevant literature. The focus is on evidence-based DiGAs approved by the Federal Institute for Drugs and Medical Devices (BfArM) for the treatment of depression and their integration into routine care as well as acceptance by patients and clinicians.

RESULTS

Internet-based cognitive behavioral therapy (iCBT) in particular, demonstrate a small to medium effect strength for depression, comparable to face-to-face therapy (Hedge's g = 0.43). Guided and blended care approaches appear to provide advantages with respect to the evidence and care; however, the utilization of DiGAs remains low, considering the large number of affected individuals, which is attributable to factors, such as limited awareness, complex access routes and prescription processes and data privacy concerns.

CONCLUSION

Despite promising evidence, the integration of DiGAs into existing healthcare systems remains challenging. Future research efforts should focus on the long-term effectiveness, personalization of digital solutions and hybrid care models to enhance acceptance and utilization.

摘要

背景

数字技术为精神健康障碍的治疗带来了新机遇。尤其是基于互联网和移动电话的干预措施(IMIs),已被证明是改善精神障碍患者护理的有效、经济高效且可及的方法。在德国,所有公共医疗保险都予以报销的数字健康应用程序(DiGAs)在日常临床实践中变得越来越重要。

目的

本文对德国医疗保健系统中与抑郁症数字健康应用程序相关的证据和挑战进行了叙述性综述。介绍了已获批的数字健康应用程序,并讨论了未来研究和护理概念的关键研究、发展情况及前景。

材料与方法

本研究基于对相关文献的叙述性综述。重点关注联邦药品和医疗器械研究所(BfArM)批准的用于治疗抑郁症的循证数字健康应用程序,及其融入常规护理的情况,以及患者和临床医生的接受度。

结果

尤其是基于互联网的认知行为疗法(iCBT),对抑郁症显示出中低等效应强度,与面对面治疗相当(赫奇斯效应量g = 0.43)。在证据和护理方面,引导式和混合式护理方法似乎具有优势;然而,考虑到大量受影响个体,数字健康应用程序的利用率仍然较低,这可归因于意识有限、获取途径和处方流程复杂以及数据隐私问题等因素。

结论

尽管有令人鼓舞的证据,但将数字健康应用程序融入现有医疗保健系统仍然具有挑战性。未来研究应侧重于长期有效性、数字解决方案的个性化以及混合护理模式,以提高接受度和利用率。

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