Iorio Alessandra, Fargnoli Maria Concetta, Sperati Francesca, Frascione Pasquale, De Simone Paola
Department of Oncological and Preventative Dermatology, San Gallicano Dermatological Institute IRCCS, Via Elio Chianesi, 00144 Rome, Italy.
UOSD Clinical Trial Center, Biostatistics and Bioinformatics, San Gallicano Dermatological Institute IRCCS, Via Elio Chianesi, 00144 Rome, Italy.
Diagnostics (Basel). 2025 Jul 25;15(15):1869. doi: 10.3390/diagnostics15151869.
Connubial melanoma, the occurrence of melanoma in non-consanguineous spouses, is rarely described in the literature. This study aimed to evaluate the prevalence of shared risk factors, preventive behaviors, and the influence of couple dynamics on the early diagnosis of cutaneous melanoma (CM). We conducted a retrospective observational study at the San Gallicano Dermatological Institute IRCCS, Rome, enrolling 52 heterosexual couples diagnosed with CM between 2010 and 2023. Clinical and anamnestic data, including phototype, history of sun exposure, use of tanning devices, and reason for dermatological evaluation, were collected. Dermatological assessments included dermoscopy, total body photography, and histological examination of excised lesions. Statistical analyses were performed using chi-square and Student's -tests. Women reported significantly higher use of artificial ultraviolet sources (51.9% vs. 19.2%, < 0.001) and more frequent histories of sunburn. Phototype II was associated with higher use of tanning devices and a greater prevalence of sunburns. Although the CM stage did not significantly differ between sexes, husbands exhibited a greater Breslow thickness. Melanoma localization differed by sex, with lower limbs more often affected in women and the trunk in men ( < 0.001). In 86.5% of cases, wives initiated their husband's dermatological evaluation, leading to earlier diagnosis. Despite shared environmental exposures, men and women differ in preventive behaviors and risk profiles. Women play a crucial role in promoting early detection among couples. Couple-based preventive strategies may be instrumental in improving early melanoma diagnosis and outcomes.
配偶性黑色素瘤，即非近亲配偶中发生的黑色素瘤，在文献中鲜有描述。本研究旨在评估共同风险因素的患病率、预防行为以及夫妻互动对皮肤黑色素瘤（CM）早期诊断的影响。我们在罗马的圣加利卡诺皮肤病研究所IRCCS进行了一项回顾性观察研究，纳入了2010年至2023年间被诊断为CM的52对异性恋夫妇。收集了临床和病史数据，包括肤色类型、日晒史、使用晒黑设备情况以及皮肤科评估原因。皮肤科评估包括皮肤镜检查、全身摄影以及切除病变的组织学检查。使用卡方检验和学生t检验进行统计分析。女性报告使用人工紫外线源的比例显著更高（51.9%对19.2%，<0.001），晒伤史也更频繁。II型肤色与更高的晒黑设备使用率和更高的晒伤患病率相关。尽管CM分期在性别之间没有显著差异，但丈夫的Breslow厚度更大。黑色素瘤的发病部位因性别而异，女性下肢更常受累，男性则是躯干（<0.001）。在86.5%的病例中，妻子促使丈夫进行皮肤科评估，从而实现了更早的诊断。尽管有共同的环境暴露，但男性和女性在预防行为和风险特征方面存在差异。女性在促进夫妻间早期发现方面发挥着关键作用。基于夫妻的预防策略可能有助于改善黑色素瘤的早期诊断和治疗结果。
