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黑色素瘤流行病学与阳光暴露。

Melanoma Epidemiology and Sun Exposure.

出版信息

Acta Derm Venereol. 2020 Jun 3;100(11):adv00136. doi: 10.2340/00015555-3491.

Abstract

The worldwide incidence of melanoma has increased rapidly over the last 50 years. Melanoma is the most common cancer found in the young adult population, and its incidence is very high among geriatric populations. The incidence of melanoma varies by sex, and this factor is also associated with differences in the anatomical site melanoma. Adolescent and young adult women have a higher incidence than men. This may be, in part, due to the greater use of sunbeds, as well as intentional sun exposure among girls and, in general, risky behaviours in seeking to suntan, due to socially-determined aesthetic needs. Indeed, the World Health Organization declared that there is sufficient evidence to classify exposure to ultraviolet radiation (sunbed use and sun exposure) as carcinogenic to humans. Although pigmentation characteristics, such as skin colour, hair and eye colour, freckles and number of common and atypical naevi, do influence susceptibility to melanoma, recommendations regarding prevention should be directed to the entire population and should include avoiding sunbed, covering sun-exposed skin, wearing a hat and sunglasses. Sunscreen use should not be used to prolong intentional sun exposure. Primary prevention should be focused mainly on young adult women, while secondary prevention should be focused mainly on elderly men. In fact, after the age of 40 years, incidence rates reverse, and the incidence of melanoma among men is greater than among women. This is probably due to the fact that men are less likely than women to examine their own skin or present to a dermatologist for skin examination.

摘要

在过去的 50 年中,全球范围内黑色素瘤的发病率迅速上升。黑色素瘤是年轻人中最常见的癌症,在老年人群中的发病率非常高。黑色素瘤的发病率因性别而异,这一因素也与黑色素瘤的解剖部位差异有关。青少年和年轻成年女性的发病率高于男性。这可能部分归因于日光浴床的使用增加,以及女孩有意晒太阳,以及由于社会审美需求而普遍存在的寻求晒黑的危险行为。事实上,世界卫生组织已经宣布,有足够的证据将紫外线辐射(使用日光浴床和暴露在阳光下)归类为对人类致癌。虽然色素沉着特征,如肤色、头发和眼睛颜色、雀斑和常见和不典型痣的数量,会影响黑色素瘤的易感性,但预防建议应该针对整个人群,包括避免使用日光浴床、遮盖暴露在阳光下的皮肤、戴帽子和太阳镜。防晒霜的使用不应用于延长有意的阳光暴露。初级预防应主要针对年轻成年女性,而二级预防应主要针对老年男性。事实上,40 岁以后,发病率会逆转,男性黑色素瘤的发病率高于女性。这可能是因为男性比女性更不可能检查自己的皮肤或向皮肤科医生进行皮肤检查。

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