Herbei Elena Emanuela, Buruiana Daniela Laura, Muresan Alina Crina, Ghisman Viorica, Bogatu Nicoleta Lucica, Basliu Vasile, Vasile Claudiu-Ionut, Barbu-Tudoran Lucian
Interdisciplinary Research Centre in the Field of Eco-Nano Technology and Advance Materials CC-ITI, Faculty of Engineering, "Dunărea de Jos" University of Galati, 47 Domnească, 800008 Galati, Romania.
Cross-Border Faculty, Cahul, "Dunărea de Jos" University of Galati, 47 Domnească Street, 800008 Galati, Romania.
Diagnostics (Basel). 2025 Jul 30;15(15):1912. doi: 10.3390/diagnostics15151912.
Magnetic nanoparticles, particularly iron oxide-based materials, such as magnetite (FeO), have gained significant attention as contrast agents in medical imaging This study aimsto syntheze and characterize FeO-based core-shell nanostructures, including FeO@TiO and FeO@SiO, and to evaluate their potential as tunable contrast agents for diagnostic imaging. FeO, FeO@TiO, and FeO@SiO nanoparticles were synthesized via co-precipitation at varying temperatures from iron salt precursors. Fourier transform infrared spectroscopy (FTIR) was used to confirm the presence of Fe-O bonds, while X-ray diffraction (XRD) was employed to determine the crystalline phases and estimate average crystallite sizes. Morphological analysis and particle size distribution were assessed by scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDX) and transmission electron microscopy (TEM). Magnetic properties were investigated using vibrating sample magnetometry (VSM). FTIR spectra exhibited characteristic Fe-O vibrations at 543 cm and 555 cm, indicating the formation of magnetite. XRD patterns confirmed a dominant cubic magnetite phase, with the presence of rutile TiO and stishovite SiO in the coated samples. The average crystallite sizes ranged from 24 to 95 nm. SEM and TEM analyses revealed particle sizes between 5 and 150 nm with well-defined core-shell morphologies. VSM measurements showed saturation magnetization (Ms) values ranging from 40 to 70 emu/g, depending on the synthesis temperature and shell composition. The highest Ms value was obtained for uncoated FeO synthesized at 94 °C. The synthesized FeO-based core-shell nanomaterials exhibit desirable structural, morphological, and magnetic properties for use as contrast agents. Their tunable magnetic response and nanoscale dimensions make them promising candidates for advanced diagnostic imaging applications.
磁性纳米颗粒，特别是基于氧化铁的材料，如磁铁矿（Fe₃O₄），作为医学成像中的造影剂受到了广泛关注。本研究旨在合成并表征基于Fe₃O₄的核壳纳米结构，包括Fe₃O₄@TiO₂和Fe₃O₄@SiO₂，并评估它们作为可调谐造影剂用于诊断成像的潜力。通过在不同温度下由铁盐前驱体共沉淀法合成了Fe₃O₄、Fe₃O₄@TiO₂和Fe₃O₄@SiO₂纳米颗粒。使用傅里叶变换红外光谱（FTIR）来确认Fe-O键的存在，同时采用X射线衍射（XRD）来确定晶相并估计平均晶粒尺寸。通过带有能量色散X射线光谱的扫描电子显微镜（SEM-EDX）和透射电子显微镜（TEM）评估形态分析和粒度分布。使用振动样品磁强计（VSM）研究磁性。FTIR光谱在543 cm⁻¹和555 cm⁻¹处显示出特征性的Fe-O振动，表明形成了磁铁矿。XRD图谱证实了主要的立方磁铁矿相，在包覆样品中存在金红石TiO₂和斯石英SiO₂。平均晶粒尺寸范围为24至95 nm。SEM和TEM分析揭示了粒径在5至150 nm之间且具有明确的核壳形态。VSM测量显示饱和磁化强度（Ms）值范围为40至70 emu/g，这取决于合成温度和壳组成。在94°C合成的未包覆Fe₃O₄获得了最高的Ms值。合成的基于Fe₃O₄的核壳纳米材料表现出用作造影剂所需的结构、形态和磁性特性。它们可调谐的磁响应和纳米级尺寸使它们成为先进诊断成像应用的有前途的候选者。
