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髋关节囊和髋臼唇退变过程的免疫组织化学与超微结构研究

Immunohistochemical and Ultrastructural Study of the Degenerative Processes of the Hip Joint Capsule and Acetabular Labrum.

作者信息

Huzum Riana Maria, Huzum Bogdan, Hînganu Marius Valeriu, Lozneanu Ludmila, Lupu Fabian Cezar, Hînganu Delia

机构信息

Department of Radiology, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 400347 Iasi, Romania.

Department of Orthopedics and Traumatology, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 400347 Iasi, Romania.

出版信息

Diagnostics (Basel). 2025 Jul 31;15(15):1932. doi: 10.3390/diagnostics15151932.

DOI:10.3390/diagnostics15151932
PMID:40804896
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12345908/
Abstract

: Degenerative processes of the hip joint increasingly affect not only the articular cartilage but also periarticular structures such as the joint capsule and acetabular labrum. This study aimed to investigate the structural and molecular changes occurring in these tissues during advanced hip osteoarthritis. : A combined analysis using immunohistochemistry (IHC), scanning electron microscopy (SEM), and micro-computed tomography (microCT) was conducted on tissue samples from patients undergoing total hip arthroplasty and from controls with morphologically normal joints. Markers associated with proliferation (Ki67), inflammation (CD68), angiogenesis (CD31, ERG), chondrogenesis (SOX9), and lubrication (Lubricin) were evaluated. : The pathological group showed increased expression of Ki67, CD68, CD31, ERG, and SOX9, with a notable decrease in Lubricin. SEM analysis revealed ultrastructural disorganization, collagen fragmentation, and neovascular remodeling in degenerative samples. A significant correlation between structural damage and molecular expression was identified. : These results suggest that joint capsule and acetabular labrum degeneration are interconnected and reflect a broader pathophysiological continuum, supporting the use of integrated IHC and SEM profiling for early detection and targeted intervention in hip joint disease.

摘要

髋关节的退行性病变不仅越来越多地影响关节软骨，还影响关节囊和髋臼唇等关节周围结构。本研究旨在调查晚期髋关节骨关节炎期间这些组织中发生的结构和分子变化。

对接受全髋关节置换术的患者以及关节形态正常的对照组的组织样本进行了免疫组织化学（IHC）、扫描电子显微镜（SEM）和微型计算机断层扫描（microCT）的联合分析。评估了与增殖（Ki67）、炎症（CD68）、血管生成（CD31、ERG）、软骨形成（SOX9）和润滑（润滑素）相关的标志物。

病理组显示Ki67、CD68、CD31、ERG和SOX9的表达增加，而润滑素显著减少。SEM分析显示退变样本中超微结构紊乱、胶原碎片形成和新生血管重塑。确定了结构损伤与分子表达之间存在显著相关性。

这些结果表明，关节囊和髋臼唇退变相互关联，反映了更广泛的病理生理连续过程，支持使用综合免疫组织化学和扫描电子显微镜分析来早期检测和靶向干预髋关节疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/a1600180f153/diagnostics-15-01932-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/18939f90520b/diagnostics-15-01932-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/c8b44d9365fe/diagnostics-15-01932-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/77b0a5f402ea/diagnostics-15-01932-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/132354351445/diagnostics-15-01932-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/a04dde551609/diagnostics-15-01932-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/0c2179c37f8d/diagnostics-15-01932-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/c332226b4064/diagnostics-15-01932-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/29cf5b30cb13/diagnostics-15-01932-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/f81a42bc1300/diagnostics-15-01932-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/2a5f6fab54f0/diagnostics-15-01932-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/4811998f17d9/diagnostics-15-01932-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/af09086d014c/diagnostics-15-01932-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/644684e2c83d/diagnostics-15-01932-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/1c963f068bb7/diagnostics-15-01932-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/20fbfafdafec/diagnostics-15-01932-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/a42c9cad0906/diagnostics-15-01932-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/d2cfbc092306/diagnostics-15-01932-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/a1600180f153/diagnostics-15-01932-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/18939f90520b/diagnostics-15-01932-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/c8b44d9365fe/diagnostics-15-01932-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/77b0a5f402ea/diagnostics-15-01932-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/132354351445/diagnostics-15-01932-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/a04dde551609/diagnostics-15-01932-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/0c2179c37f8d/diagnostics-15-01932-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/c332226b4064/diagnostics-15-01932-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/29cf5b30cb13/diagnostics-15-01932-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/f81a42bc1300/diagnostics-15-01932-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/2a5f6fab54f0/diagnostics-15-01932-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/4811998f17d9/diagnostics-15-01932-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/af09086d014c/diagnostics-15-01932-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/644684e2c83d/diagnostics-15-01932-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/1c963f068bb7/diagnostics-15-01932-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/20fbfafdafec/diagnostics-15-01932-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/a42c9cad0906/diagnostics-15-01932-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/d2cfbc092306/diagnostics-15-01932-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/12345908/a1600180f153/diagnostics-15-01932-g018.jpg

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