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囊性畸胎瘤中的黏液性癌、黏液性交界性肿瘤及卵巢假黏液瘤:一个组织学难题

Mucinous Carcinoma, Mucinous Borderline Tumor and Pseudomyxoma Ovarii in a Cystic Teratoma: A Histological Conundrum.

作者信息

Giacometti Cinzia, Mirandola Mariateresa, Aliberti Camillo, Molinari Filippo, Marcolini Lisa, Mautone Daniele, Martignoni Guido

机构信息

Pathology Unit, Pederzoli Hospital, Peschiera del Garda, 37019 Verona, Italy.

Gynecology & Obstetrics Unit, Pederzoli Hospital, Peschiera del Garda, 37019 Verona, Italy.

出版信息

Diagnostics (Basel). 2025 Aug 4;15(15):1957. doi: 10.3390/diagnostics15151957.

DOI:10.3390/diagnostics15151957
PMID:40804920
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12346603/
Abstract

Mature teratomas account for approximately 20% of all ovarian tumors identified in pathological studies. Benign or malignant somatic neoplasms developing within teratomas can arise from any tissue in up to 2% of mature cystic teratomas, including low-grade malignant mucinous neoplasms. This report presents the case of a 34-year-old woman with no previous gynecological or general health issues, who was admitted to our Hospital after an asymptomatic pelvic mass was detected during a routine exam. A transvaginal ultrasound revealed a unilateral pelvic mass in the left adnexal region, measuring 8 cm. The CT scan showed a cystic-appearing formation measuring nearly 12 cm, which indented the bladder dome. Final diagnosis indicated a mucinous carcinoma arising from a mucinous borderline lesion within the context of a mature ovarian teratoma. No other involvement or lymphadenopathies were detected on 18FDG-PET CT scan, and the patient is now well and free of recurrences.

摘要

成熟畸胎瘤约占病理研究中所有卵巢肿瘤的20%。在畸胎瘤内发生的良性或恶性体细胞肿瘤,在高达2%的成熟囊性畸胎瘤中可源自任何组织,包括低级别恶性黏液性肿瘤。本报告介绍了一名34岁女性的病例,该女性既往无妇科或全身健康问题,在一次常规检查中发现无症状盆腔肿块后入住我院。经阴道超声显示左侧附件区有一个单侧盆腔肿块,大小为8厘米。CT扫描显示一个近12厘米的囊性结构,压迫膀胱顶部。最终诊断为成熟卵巢畸胎瘤背景下由黏液性交界性病变引起的黏液癌。18FDG-PET CT扫描未发现其他受累情况或淋巴结病变,患者目前情况良好,无复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fada/12346603/c662dd127d72/diagnostics-15-01957-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fada/12346603/c5767cf474a7/diagnostics-15-01957-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fada/12346603/97a2a32e6f6b/diagnostics-15-01957-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fada/12346603/746907d6654e/diagnostics-15-01957-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fada/12346603/c662dd127d72/diagnostics-15-01957-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fada/12346603/c5767cf474a7/diagnostics-15-01957-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fada/12346603/d44c41ef6acd/diagnostics-15-01957-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fada/12346603/03ceba7ae268/diagnostics-15-01957-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fada/12346603/97a2a32e6f6b/diagnostics-15-01957-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fada/12346603/746907d6654e/diagnostics-15-01957-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fada/12346603/c662dd127d72/diagnostics-15-01957-g006.jpg

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本文引用的文献

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Mucinous neoplasms associated with mature cystic teratomas: A clinicopathologic study of 50 cases: Are we ready for nomenclature change?与成熟囊性畸胎瘤相关的黏液性肿瘤:50例临床病理研究:我们是否准备好进行命名更改?
Ann Diagn Pathol. 2025 Oct;78:152494. doi: 10.1016/j.anndiagpath.2025.152494. Epub 2025 Apr 23.
2
Molecular characterization of ovarian squamous cell carcinoma originating from mature teratoma.源自成熟畸胎瘤的卵巢鳞状细胞癌的分子特征
J Mol Med (Berl). 2025 Jan;103(1):101-111. doi: 10.1007/s00109-024-02505-w. Epub 2024 Dec 4.
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Fertility-sparing treatment and follow-up in patients with cervical cancer, ovarian cancer, and borderline ovarian tumours: guidelines from ESGO, ESHRE, and ESGE.
保留生育功能治疗及随访宫颈癌、卵巢癌和交界性卵巢肿瘤患者:来自 ESGO、ESHRE 和 ESGE 的指南。
Lancet Oncol. 2024 Nov;25(11):e602-e610. doi: 10.1016/S1470-2045(24)00262-6. Epub 2024 Aug 28.
4
Ovarian Causes of Pseudomyxoma Peritonei (PMP)-A Literature Review.腹膜假黏液瘤(PMP)的卵巢病因——文献综述
Cancers (Basel). 2024 Apr 9;16(8):1446. doi: 10.3390/cancers16081446.
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ESGO-ESMO-ESP consensus conference recommendations on ovarian cancer: pathology and molecular biology and early, advanced and recurrent disease.ESGO-ESMO-ESP 共识会议关于卵巢癌的建议:病理学和分子生物学以及早期、晚期和复发性疾病。
Ann Oncol. 2024 Mar;35(3):248-266. doi: 10.1016/j.annonc.2023.11.015. Epub 2024 Feb 1.
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Low-grade mucinous neoplasm arising from mature ovarian teratoma with pseudomyxoma peritonei.起源于成熟卵巢畸胎瘤并伴有腹膜假黏液瘤的低级别黏液性肿瘤。
Int J Gynecol Cancer. 2023 Jun 5;33(6):1005-1006. doi: 10.1136/ijgc-2022-004099.
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J Obstet Gynaecol Res. 2022 Dec;48(12):3068-3076. doi: 10.1111/jog.15409. Epub 2022 Sep 2.
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