Keven Mehmet Can, Aydoğdu Ece, Derim Yeğen Banu, Yucel Ebru, Bütün Zafer, Tanaçan Atakan
Department of Gynecology and Obstetrics, Division of Perinatology, Eskişehir City Hospital, Eskişehir 26080, Turkey.
Department of Gynecology and Obstetrics, Eskişehir City Hospital, Eskişehir 26080, Turkey.
J Clin Med. 2025 Aug 1;14(15):5414. doi: 10.3390/jcm14155414.
The objective of this study was to investigate the relationship between the simultaneous 75 g Oral glucose tolerance test (OGTT), gestational diabetes mellitus (GDM), and fetal pancreatic circumference at 24-28 weeks of gestation. This prospective case-control study was conducted between September 2024 and February 2025 at our perinatology clinic, which provides tertiary health care services. The correlation between the 75 g OGTT, GDM, and pancreatic circumference was assessed by comparing fetal pancreatic circumference between the groups with and without GDM at the time of diagnosis. A total of 130 pregnant patients were recruited for this` study, with 64 patients forming the GDM group and 66 patients forming the control group. Fetal pancreas circumference (7.0 cm vs. 6.4 cm, < 0.001), fetal pancreas circumference percentile (88.5 vs. 52, < 0.001), and the rate of fetal pancreas size >90th percentile (15.6% vs. 3%, < 0.001) were significantly higher in the GDM group compared to the control group. Although our findings demonstrate a statistically significant correlation between fetal pancreatic circumference and GDM, diagnostic performance remains modest. Therefore, fetal pancreatic circumference should be interpreted as a supportive marker, such as family history, rather than a definitive marker for identifying individuals at risk for GDM.
本研究的目的是调查妊娠24 - 28周时同步进行的75克口服葡萄糖耐量试验（OGTT）、妊娠期糖尿病（GDM）与胎儿胰腺周长之间的关系。这项前瞻性病例对照研究于2024年9月至2025年2月在我们提供三级医疗保健服务的围产医学诊所进行。通过比较诊断时患有和未患有GDM的两组胎儿胰腺周长，评估75克OGTT、GDM与胰腺周长之间的相关性。本研究共招募了130名孕妇，其中64名患者组成GDM组，66名患者组成对照组。GDM组的胎儿胰腺周长（7.0厘米对6.4厘米，<0.001）、胎儿胰腺周长百分位数（88.5对52，<0.001）以及胎儿胰腺大小>第90百分位数的比例（15.6%对3%，<0.001）均显著高于对照组。尽管我们的研究结果表明胎儿胰腺周长与GDM之间存在统计学上的显著相关性，但诊断性能仍然一般。因此，胎儿胰腺周长应被解释为一种辅助标志物，如家族史，而不是用于识别GDM风险个体的确定性标志物。
