Skowrońska Magdalena, Pawłowski Michał, Dyszkiewicz Aleksandra, Buczyńska Angelika, Milewski Robert
Doctoral School, Medical University of Bialystok, 15-276 Bialystok, Poland.
Department of Biostatistics and Medical Informatics, Medical University of Bialystok, 15-295 Bialystok, Poland.
J Clin Med. 2025 Aug 6;14(15):5527. doi: 10.3390/jcm14155527.
Asprosin is a relatively recently discovered glucogenic adipokine secreted during fasting that plays an important role in various biochemical processes in the body, including those connected with obesity and insulin resistance. The aim of this exploratory study was to investigate the associations between selected hormonal, anthropometric, and lifestyle-related parameters and serum asprosin concentration. As studies concerning fertility and asprosin have so far been limited to men or women with PCOS, its role in the general female population remains largely unexplored. The direction of this exploration was thus pointed toward possible connections with female fertility. The case-control study group included 56 women of reproductive age (25-42 years), who were patients of the Reproductive Health Clinic and the Clinic of Endocrinology, Diabetology, and Internal Medicine of the Medical University of Białystok, Poland. The levels of selected hormones, including anti-Müllerian hormone (AMH), estradiol, sex hormone-binding globulin (SHBG), and testosterone, body composition parameters, and a lifestyle parameter-night fasting duration-were assessed to test their associations with serum asprosin concentration. A weak negative correlation was found between AMH level and serum asprosin concentration, suggesting a potential link between asprosin and ovarian reserve. Furthermore, a moderate positive correlation was found between the percentage of total body water (TBW) and serum asprosin concentration. No significant associations were observed between the levels of the other tested hormones and serum asprosin concentration, or between body composition parameters or night fasting duration and serum asprosin concentration. The multivariate model designed in the study shows that AMH, TBW, and night fasting duration explain 23.4% of asprosin variability. Although the nature of the study is exploratory, the findings indicate that the role of asprosin in the female population-particularly its role in fertility-requires further research. Not only is the number of available studies on asprosin insufficient, but the results of this study partly contradict what is known about the hormone from previous studies, which were largely performed with male cohorts. In addition, the results of this study suggest that asprosin may indeed be involved in mechanisms related to female fertility, particularly those connected with ovarian reserve. Nevertheless, studies performed in larger, more homogeneous populations are necessary to confirm the role of asprosin in women, including its association with female fertility.
阿朴脂蛋白是一种相对较新发现的生糖脂肪因子，在禁食期间分泌，在身体的各种生化过程中发挥重要作用，包括与肥胖和胰岛素抵抗相关的过程。这项探索性研究的目的是调查选定的激素、人体测量学和生活方式相关参数与血清阿朴脂蛋白浓度之间的关联。由于迄今为止关于生育力和阿朴脂蛋白的研究仅限于患有多囊卵巢综合征的男性或女性，其在一般女性人群中的作用在很大程度上仍未得到探索。因此，这项探索的方向指向了与女性生育力的可能联系。病例对照研究组包括56名育龄妇女（25 - 42岁），她们是波兰比亚韦斯托克医科大学生殖健康诊所以及内分泌、糖尿病和内科诊所的患者。评估了选定激素的水平，包括抗苗勒管激素（AMH）、雌二醇、性激素结合球蛋白（SHBG）和睾酮、身体成分参数以及一个生活方式参数——夜间禁食时长，以测试它们与血清阿朴脂蛋白浓度的关联。发现AMH水平与血清阿朴脂蛋白浓度之间存在弱负相关，这表明阿朴脂蛋白与卵巢储备之间可能存在联系。此外，发现全身水含量（TBW）百分比与血清阿朴脂蛋白浓度之间存在中度正相关。在其他测试激素水平与血清阿朴脂蛋白浓度之间，或身体成分参数或夜间禁食时长与血清阿朴脂蛋白浓度之间未观察到显著关联。该研究设计的多变量模型表明，AMH、TBW和夜间禁食时长解释了阿朴脂蛋白变异性的23.4%。尽管该研究的性质是探索性的，但研究结果表明阿朴脂蛋白在女性人群中的作用——特别是其在生育力方面的作用——需要进一步研究。不仅关于阿朴脂蛋白的现有研究数量不足，而且本研究的结果部分与先前研究中关于该激素的已知情况相矛盾，先前的研究大多是在男性队列中进行的。此外，本研究的结果表明阿朴脂蛋白可能确实参与了与女性生育力相关的机制，特别是那些与卵巢储备相关的机制。然而，需要在更大、更同质的人群中进行研究，以确认阿朴脂蛋白在女性中的作用，包括其与女性生育力的关联。
