Skowrońska Magdalena, Pawłowski Michał, Buczyńska Angelika, Wiatr Aleksandra, Dyszkiewicz Aleksandra, Wenta Aleksandra, Gryko Kamila, Zbucka-Krętowska Monika, Milewski Robert
Doctoral School, Medical University of Bialystok, 15-276 Bialystok, Poland.
Department of Biostatistics and Medical Informatics, Medical University of Bialystok, 15-295 Bialystok, Poland.
Nutrients. 2024 Nov 29;16(23):4149. doi: 10.3390/nu16234149.
The aim of this study was to outline the relationships between selected parameters connected with lifestyle and serum anti-Müllerian hormone (AMH) levels, i.e., a marker of ovarian reserve. By examining AMH levels in connection with nutrient intake and body composition parameters, this study aimed to provide a preliminary background for further studies focused on establishing dietary and lifestyle recommendations that could lead to improvements in fertility outcomes. The research involved 28 women, aged 26 to 42-both with and without ovulatory infertility-who were patients of the Reproductive Health Clinic at the Medical University of Białystok. The participants underwent a number of tests consisting of hormonal profiling, including AMH measurements, body composition analyses, and dietary assessments based on a 3-day food diary. The findings of the study indicate that certain lifestyle factors are associated with changes in AMH levels. Most importantly, the multivariate linear regression model designed in the study shows that age, waist-to-hip ratio (WHR), as well as the intake of sucrose, iodine, and erucic acid explain variations in serum AMH levels. These results support the hypothesis that modifiable lifestyle factors can influence AMH levels, and thus ovarian reserve. The study underscores the potential for targeted lifestyle interventions to support fertility and calls for further research in the form of prospective studies performed in larger groups of patients to substantiate these associations and inform fertility care strategies. Based on the preliminary results of this study, certain dietary ideas that could positively influence fertility have been proposed, focused on the normalization of body weight and the reduction in excess fat tissue.
本研究的目的是概述与生活方式相关的特定参数与血清抗苗勒管激素(AMH)水平之间的关系,AMH是卵巢储备的一个标志物。通过研究AMH水平与营养摄入及身体成分参数之间的联系,本研究旨在为进一步的研究提供初步背景,这些研究聚焦于制定可改善生育结局的饮食和生活方式建议。该研究纳入了28名年龄在26至42岁之间的女性,她们均为白俄罗斯医科大学生殖健康诊所的患者,有无排卵性不孕症者皆有。参与者接受了一系列检测,包括激素分析(其中有AMH测量)、身体成分分析以及基于3天饮食日记的饮食评估。研究结果表明,某些生活方式因素与AMH水平的变化相关。最重要的是,本研究设计的多元线性回归模型显示,年龄、腰臀比(WHR)以及蔗糖、碘和芥酸的摄入量可解释血清AMH水平的变化。这些结果支持了可改变的生活方式因素会影响AMH水平,进而影响卵巢储备的假设。该研究强调了针对性生活方式干预对支持生育的潜力,并呼吁开展更大规模患者群体的前瞻性研究,以证实这些关联并为生育护理策略提供参考。基于本研究的初步结果,已提出了某些可能对生育产生积极影响的饮食建议,重点是体重正常化和减少多余脂肪组织。