Godela Agnieszka, Rogacz Diana, Pawłowska Barbara, Biczak Robert
The Faculty of Science and Technology, Jan Długosz University in Czestochowa, 13/15 Armii Krajowej Av., 42-200 Czestochowa, Poland.
Molecules. 2025 Jul 28;30(15):3158. doi: 10.3390/molecules30153158.
Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis remain incurable. Current therapeutic strategies primarily focus on slowing disease progression, alleviating symptoms, and improving patients' quality of life, including the management of comorbid conditions. Over the past few decades, the incidence of diagnosed neurodegenerative disorders has risen significantly. As the number of affected individuals continues to grow, so does the urgent need for effective treatments that can halt or mitigate the progression of these diseases. Among the most promising therapeutic resources are bioactive compounds derived from fungi. The high quality of proteins, polysaccharides, unsaturated fatty acids, triterpenoids, sterols, and secondary metabolites found in fungi have attracted growing interest from researchers across multiple disciplines. One intensively studied direction involves the use of naturally occurring fungi-derived nutraceuticals in the treatment of various diseases, including neurodegenerative conditions. This article provides an overview of recent findings on fungal compounds-such as phenolic compounds, carbohydrates, peptides and proteins, and lipids-that may have potential applications in the treatment of neurodegenerative diseases and the alleviation of their symptoms.
阿尔茨海默病、帕金森病、亨廷顿舞蹈病和肌萎缩侧索硬化症等神经退行性疾病仍然无法治愈。当前的治疗策略主要集中在减缓疾病进展、缓解症状以及提高患者生活质量，包括对合并症的管理。在过去几十年中，已诊断出的神经退行性疾病的发病率显著上升。随着受影响个体数量的持续增加，对能够阻止或减轻这些疾病进展的有效治疗方法的迫切需求也在增加。最有前景的治疗资源之一是源自真菌的生物活性化合物。真菌中发现的高质量蛋白质、多糖、不饱和脂肪酸、三萜类化合物、甾醇和次生代谢产物引起了多个学科研究人员越来越多的关注。一个深入研究的方向涉及使用天然存在的真菌源营养保健品来治疗各种疾病，包括神经退行性疾病。本文概述了关于真菌化合物（如酚类化合物、碳水化合物、肽和蛋白质以及脂质）的最新研究结果，这些化合物可能在治疗神经退行性疾病及其症状缓解方面具有潜在应用。
