Stam Rianne
Centre for Sustainability, Environment and Health, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Electromagn Biol Med. 2025 Aug 3:1-15. doi: 10.1080/15368378.2025.2540435.
Epidemiological studies have found an association between occupational exposure to low frequency magnetic fields and the occurrence of motor neuron disease and Alzheimer's disease. No association has been found for Parkinson's disease and the evidence for multiple sclerosis is insufficient. Animal models studying the effects of low frequency magnetic fields on neurodegenerative disease induction or progression could provide more evidence on causation and the underlying mechanisms. A systematic search and review was conducted of peer-reviewed research articles involving animal experiments on the effects of low frequency magnetic field exposure on behavioural and neuroanatomical outcomes relevant for neurodegenerative diseases in humans. Firstly, experimental studies in do not support a causal relationship between exposure to low frequency magnetic fields and the induction of neuropathology relevant for Alzheimer's disease, but the number of studies relevant for motor neuron disease, multiple sclerosis and Parkinson's disease is too limited to draw conclusions. Secondly, experimental studies in support a therapeutic (beneficial) effect of low frequency magnetic field treatment on behavioural and neuroanatomical abnormalities relevant for dementia (including Alzheimer's disease), multiple sclerosis and Parkinson's disease and no effect on disease progression in models relevant for motor neuron disease.
流行病学研究发现，职业暴露于低频磁场与运动神经元病和阿尔茨海默病的发生之间存在关联。未发现与帕金森病有关联，而关于多发性硬化症的证据不足。研究低频磁场对神经退行性疾病诱发或进展影响的动物模型可以为因果关系及潜在机制提供更多证据。我们对同行评审的研究文章进行了系统检索和综述，这些文章涉及关于低频磁场暴露对与人类神经退行性疾病相关的行为和神经解剖学结果影响的动物实验。首先，[此处信息缺失]的实验研究不支持低频磁场暴露与阿尔茨海默病相关神经病理学诱发之间存在因果关系，但与运动神经元病、多发性硬化症和帕金森病相关的研究数量过于有限，无法得出结论。其次，[此处信息缺失]的实验研究支持低频磁场治疗对与痴呆（包括阿尔茨海默病）、多发性硬化症和帕金森病相关的行为和神经解剖学异常具有治疗（有益）作用，而对与运动神经元病相关模型中的疾病进展没有影响。
