Ph.D. Program for Biotechnology Industry, College of Life Sciences, China Medical University, Taichung 404, Taiwan.
Department of Cosmeceutics, College of Pharmacy, China Medical University, Taichung 404, Taiwan.
Molecules. 2022 Apr 4;27(7):2332. doi: 10.3390/molecules27072332.
Skin aging is a complex process involving photoaging and glycation stress, which share some fundamental pathways and have common mediators. They can cause skin damage and collagen degradation by inducing oxidative stress and the accumulation of reactive oxygen species (ROS). (CF), also known as Djulis, is a traditional cereal in Taiwan. This study investigated the protection mechanisms of CF extract against ultraviolet (UV) radiation and advanced glycation end products (AGEs)-induced stress. The results indicated that CF extract had strong antioxidant and free radical scavenging effects. It could reduce UV-induced intracellular ROS generation and initiate the antioxidant defense system by activating the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway in human skin fibroblasts. CF extract modulated mitogen-activated protein kinase (MAPK) and transformed growth factor-beta (TGF-β) signaling pathways to alleviate oxidative stress-induced skin aging. Moreover, the results revealed that CF extract not only promoted collagen synthesis but also improved aging-induced collagen degradation. CF extract attenuated AGEs-induced ROS production and the upregulation of receptor for AGEs (RAGE). The overall results suggest that CF extract provides an effective anti-aging strategy by preventing skin damage from oxidative stress and collagen loss with potent antioxidant, anti-photoaging, and antiglycation activities.
皮肤衰老过程复杂，涉及光老化和糖基化应激，它们有一些共同的途径和共同的介质。它们通过诱导氧化应激和活性氧（ROS）的积累，导致皮肤损伤和胶原蛋白降解。（CF），又称 Djulis，是台湾的一种传统谷物。本研究探讨了 CF 提取物对紫外线（UV）辐射和晚期糖基化终产物（AGEs）诱导应激的保护机制。结果表明，CF 提取物具有很强的抗氧化和自由基清除作用。它可以减少 UV 诱导的细胞内 ROS 生成，并通过激活人皮肤成纤维细胞中的核因子红细胞 2 相关因子 2（Nrf2）/血红素加氧酶-1（HO-1）信号通路，启动抗氧化防御系统。CF 提取物调节丝裂原激活蛋白激酶（MAPK）和转化生长因子-β（TGF-β）信号通路，以减轻氧化应激诱导的皮肤衰老。此外，结果表明 CF 提取物不仅促进胶原蛋白合成，还改善了老化诱导的胶原蛋白降解。CF 提取物可减轻 AGEs 诱导的 ROS 产生和受体 AGEs（RAGE）的上调。总体结果表明，CF 提取物通过防止氧化应激和胶原蛋白损失提供了一种有效的抗衰老策略，具有强大的抗氧化、抗光老化和抗糖化活性。
