Hienz R D, Brady J V, Bowers D A, Ator N A
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21206.
Drug Alcohol Depend. 1989 Dec;24(3):213-25. doi: 10.1016/0376-8716(89)90058-6.
Baboons were trained to ingest ethanol at successively higher ethanol concentrations using oral self-administration techniques. Concurrently, animal psychophysical procedures were employed to determine auditory thresholds and reaction times daily. Maximal consumption of ethanol occurred at concentrations of 6-8% (w/v). During the initial period of ethanol self-administration, both auditory reaction times and auditory thresholds became elevated as animals consumed larger amounts of ethanol. For both the threshold and reaction time measures, the degree of elevation was correlated with the amount of ethanol consumed. These correlations decreased, however, with continued ethanol consumption. The elevations in sensory and motor function recovered to near-baseline levels when ethanol was no longer available.
使用口服自我给药技术训练狒狒摄入乙醇浓度逐渐升高的乙醇。同时，每天采用动物心理物理学程序来确定听觉阈值和反应时间。乙醇的最大摄入量出现在浓度为6 - 8%（重量/体积）时。在乙醇自我给药的初始阶段，随着动物摄入大量乙醇，听觉反应时间和听觉阈值均升高。对于阈值和反应时间测量，升高程度与乙醇摄入量相关。然而，随着乙醇持续摄入，这些相关性降低。当不再提供乙醇时，感觉和运动功能的升高恢复到接近基线水平。
