Yamaguchi K, Nabeshima T, Amano M, Yoshida S, Furukawa H, Kameyama T
Pharmacol Biochem Behav. 1985 Nov;23(5):803-9. doi: 10.1016/0091-3057(85)90075-9.
This study was designed to assess whether phencyclidine (PCP) produces dopamine (DA)-dependent behaviors such as licking, biting and gnawing at low doses after withdrawal from chronic haloperidol (HAL) treatment in rats. Low doses of PCP (2.5 and 5 mg/kg) produced licking, gnawing, biting and self-biting in rats after withdrawal from chronic HAL treatment, which were not observed in the vehicle-pretreated rats given PCP at the same dose range. These behaviors were similar to DA-dependent behaviors produced by methamphetamine and apomorphine in rats after withdrawal from chronic HAL treatment. The PCP-induced behaviors were attenuated by acute pretreatment of DA antagonist, HAL (0.25 mg/kg, IP). Furthermore, at doses of 5 or 7.5 mg/kg, PCP-induced head weaving and backpedalling, which were mediated by both DA and serotonin (5-HT) neurons, significantly increased in rats after withdrawal from chronic HAL-treatment. These results suggest that dopaminergic systems play an important role for PCP-induced behavioral responses.
本研究旨在评估在大鼠慢性氟哌啶醇（HAL）治疗停药后，苯环己哌啶（PCP）在低剂量时是否会产生如舔舐、啃咬和咬噬等依赖多巴胺（DA）的行为。低剂量的PCP（2.5和5毫克/千克）在大鼠慢性HAL治疗停药后会引发舔舐、啃咬、咬噬和自咬行为，而在相同剂量范围内给予PCP的溶媒预处理大鼠中未观察到这些行为。这些行为类似于大鼠在慢性HAL治疗停药后由甲基苯丙胺和阿扑吗啡产生的依赖DA的行为。PCP诱导的行为可通过DA拮抗剂HAL（0.25毫克/千克，腹腔注射）的急性预处理而减弱。此外，在5或7.5毫克/千克的剂量下，由DA和5-羟色胺（5-HT）神经元介导的PCP诱导的头部摆动和倒退行为，在大鼠慢性HAL治疗停药后显著增加。这些结果表明，多巴胺能系统在PCP诱导的行为反应中起重要作用。
