氯氮䓬对脑厌恶电刺激诱发的心血管和呼吸变化的抑制作用。

Depressant action of chlordiazepoxide on cardiovascular and respiratory changes induced by aversive electrical stimulation of the brain.

Schenberg L C, de Aguiar J C, Salgado H C, Graeff F G

Braz J Med Biol Res. 1981 Apr;14(1):69-72.

Abstract

Electrical stimulation of the dorsal periaqueductal gray matter (DPAG), an aversive area of the rat brain, increased the mean blood pressure of awake rats as well as of animals anesthetized with urethane. 2. In the anesthetized rats, increases in heart rate and in breath rate were also induced by DPAG stimulation. 3. Chlordiazepoxide, a benzodiazepine, decreased the blood pressure rise caused by aversive stimulation of the brain in the awake rat. 4. Chlordiazepoxide elicited the same effect in urethane-anesthetized rats. In addition, the hyperpnea induced by electrical stimulation of the dorsal periaqueductal gray matter was also decreased by the drug. 5. The pressor response to intravenous noradrenaline was not affected by chlordiazepoxide. 6. These results suggest that benzodiazepines attenuate the neurovegetative changes accompanying emotion by depressing brain systems that integrate emotional behavior.

摘要

对大鼠脑内的厌恶区域——中脑导水管周围灰质背侧（DPAG）进行电刺激，可使清醒大鼠以及用乌拉坦麻醉的动物的平均血压升高。2. 在麻醉大鼠中，刺激DPAG还可引起心率和呼吸频率增加。3. 苯二氮䓬类药物氯氮䓬可降低清醒大鼠因脑厌恶刺激引起的血压升高。4. 氯氮䓬在乌拉坦麻醉的大鼠中产生相同的效果。此外，该药物还可降低电刺激中脑导水管周围灰质背侧所诱发的呼吸急促。5. 氯氮䓬对静脉注射去甲肾上腺素引起的升压反应没有影响。6. 这些结果表明，苯二氮䓬类药物通过抑制整合情绪行为的脑系统，减轻伴随情绪出现的神经植物性变化。