Moreau J L, Schmitt P, Karli P
Pharmacol Biochem Behav. 1985 Dec;23(6):931-6. doi: 10.1016/0091-3057(85)90095-4.
In the rat, a microinjection of 15 nmoles of morphine into the ventral tegmentum (VT) was found to suppress escape responding induced by electrical stimulation applied to the dorsal part of the mesencephalic central gray. This suppressant effect could be reversed by a systemic injection of naloxone and was unlikely to be due to gross motor impairment since morphine injected into the VT provoked a behavioral activation. A similar microinjection of morphine into the VT did not induce analgesic effects since it did not affect the reaction thresholds to a nociceptive stimulus. The mechanisms underlying these differential effects of morphine applied to the VT are discussed.
在大鼠中，向腹侧被盖区（VT）微量注射15纳摩尔吗啡，可抑制由施加于中脑中央灰质背侧的电刺激所诱发的逃避反应。这种抑制作用可通过全身注射纳洛酮逆转，且不太可能是由于严重的运动障碍，因为向VT注射吗啡会引发行为激活。向VT进行类似的吗啡微量注射不会产生镇痛作用，因为它不影响对伤害性刺激的反应阈值。文中讨论了应用于VT的吗啡产生这些不同效应的潜在机制。
