He Yuxing, Luo Can, Du Wei, Liu Debei, Liao Lingshan, Wang Siqian, Cao Yanlin
Clinical Laboratory Department, Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City), Changde, Hunan 415000, P.R. China.
Department of Pathology, Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City), Changde, Hunan 415000, P.R. China.
Oncol Rep. 2025 Nov;54(5). doi: 10.3892/or.2025.8972. Epub 2025 Aug 14.
Circular RNAs (circRNAs) are stable, conserved non‑coding RNA molecules with key roles in gene regulation. Because of their tissue‑specific expression patterns and involvement in various cellular processes, circRNAs are relevant in cancer biology, specifically for colorectal cancer (CRC) diagnosis. The present review systematically examines the roles of circRNAs in CRC pathogenesis and their potential as diagnostic biomarkers and therapeutic targets for CRC, focusing on the key circRNAs involved in CRC development and progression, their molecular mechanisms and clinical value, as well as advances in circRNA‑based therapeutic strategies and challenges in the clinical translation of circRNA application.
环状RNA（circRNAs）是稳定、保守的非编码RNA分子，在基因调控中起关键作用。由于其组织特异性表达模式以及参与各种细胞过程，circRNAs与癌症生物学相关，特别是在结直肠癌（CRC）诊断方面。本综述系统地研究了circRNAs在CRC发病机制中的作用及其作为CRC诊断生物标志物和治疗靶点的潜力，重点关注参与CRC发生和发展的关键circRNAs、它们的分子机制和临床价值，以及基于circRNAs的治疗策略的进展和circRNA应用临床转化中的挑战。
