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[关注声明] 赖氨酸去甲基化酶2A通过调节PI3K通路和逆转上皮-间质转化促进卵巢癌进展。

[Expression of Concern] Lysine demethylase 2A promotes the progression of ovarian cancer by regulating the PI3K pathway and reversing epithelial‑mesenchymal transition.

作者信息

Lu Dan-Hua, Yang Jiang, Gao Li-Kun, Min Jie, Tang Jian-Ming, Hu Ming, Li Yang, Li Su-Ting, Chen Jing, Hong Li

机构信息

Department of Gynaecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

Department of Pathology, Molecular Diagnostics Laboratory, University of Michigan, Ann Arbor, MI 48109, USA.

出版信息

Oncol Rep. 2025 Nov;54(5). doi: 10.3892/or.2025.8971. Epub 2025 Aug 14.

Abstract

Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that one of the colony‑formation assay images shown in Fig. 2D for the SKOV3 experiments was strikingly similar to the 'SKOV3/0 µM LY294002' image shown in Fig. 5E, if one of the dishes were to be rotated 90°. Upon performing an independent analysis of the data in this paper in the Editorial Office, it also came to light that the data shown for the MMP9 blot (A2780 cell line) in Fig. 4E was strikingly similar to the p‑mTOR blot (again for the A2780 cell line) in Fig. 5B, suggesting that one of these figures had been assembled incorrectly. The authors were contacted by the Editorial Office to offer an explanation for these apparent anomalies in the presentation of the data in this paper; however, up to this time, no response from them has been forthcoming. Owing to the fact that the Editorial Office has been made aware of potential issues surrounding the scientific integrity of this paper, we are issuing an Expression of Concern to notify readers of this potential problem while the Editorial Office continues to investigate this matter further. [Oncology Reports 41: 917‑927, 2019; DOI: 10.3892/or.2018.6888].

摘要

在本文发表后,一位关注此事的读者提醒编辑注意,在SKOV3实验的图2D中所示的一个集落形成测定图像,如果将其中一个培养皿旋转90°,与图5E中所示的“SKOV3/0 μM LY294002”图像惊人地相似。编辑部在对本文数据进行独立分析时还发现,图4E中所示的MMP9印迹(A2780细胞系)的数据与图5B中所示的p-mTOR印迹(同样是A2780细胞系)惊人地相似,这表明这些图中的一张组装有误。编辑部已与作者联系,要求对本文数据呈现中的这些明显异常作出解释;然而,截至目前,尚未收到他们的回复。由于编辑部已意识到围绕本文科学完整性的潜在问题,我们特此发布关注声明,在编辑部继续进一步调查此事的同时,告知读者这一潜在问题。[《肿瘤学报道》41: 917-927, 2019;DOI: 10.3892/or.2018.6888]

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