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[关注声明] 微小RNA-195靶向血管内皮生长因子受体2,并通过PI3K/Akt和Raf/MEK/ERK信号通路在ACHN细胞中发挥肿瘤抑制作用。

[Expression of Concern] MicroRNA‑195 targets VEGFR2 and has a tumor suppressive role in ACHN cells via PI3K/Akt and Raf/MEK/ERK signaling pathways.

作者信息

Sun Pengcheng, Wang Lu, Lu Yunhan, Liu Yuwei, Li Lechen, Yin Luyao, Zhang Cheng, Zhao Weiming, Shen Baozhong, Xu Wanhai

机构信息

Department of Urology, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.

Department of Urology, The First Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.

出版信息

Int J Oncol. 2025 Nov;67(5). doi: 10.3892/ijo.2025.5792. Epub 2025 Aug 24.

Abstract

Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that, regarding the Transwell migration and invasion assay data shown in Fig. 3A and B, two pairs of panels appeared to contain overlapping sections of data (out of a total of ten panels), such that data which were intended to show the results from differently performed experiments appeared to have been derived from the same original sources. Upon analyzing the data independently in the Editorial Office, a third pair of data panels in the same figure were found to be similarly affected. The authors were contacted by the Editorial Office to offer an explanation for these apparent anomalies in the presentation of the data in this paper, although up to this time, no response from them has been forthcoming. Owing to the fact that the Editorial Office has been made aware of potential issues surrounding the scientific integrity of this paper, we are issuing an Expression of Concern to notify readers of this potential problem while the Editorial Office conitnues to investigate this matter further. [International Journal of Oncology 49: 1155‑1163, 2016; DOI: 10.3892/ijo.2016.3608].

摘要

上述论文发表后,一位关切的读者提醒编辑注意,关于图3A和B所示的Transwell迁移和侵袭实验数据,两对图板(总共十对图板)似乎包含重叠的数据部分,以至于本应显示不同实验结果的数据似乎来自相同的原始来源。编辑部独立分析数据时,发现同一图中的第三对数据图板也受到类似影响。编辑部已联系作者,要求其对本文数据呈现中这些明显的异常情况作出解释,但截至目前,尚未收到他们的回复。鉴于编辑部已意识到围绕本文科学诚信的潜在问题,我们特此发布关注声明,在编辑部继续进一步调查此事的同时,告知读者这一潜在问题。[《国际肿瘤学杂志》49: 1155 - 1163, 2016; DOI: 10.3892/ijo.2016.3608]

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