Liu Sitong, Xu Yaxin, Xie Jinhan, Hu Jing, Wang Yuetong, Zhang Junhua, Lee Myeong Soo, Hu Haiyin, Ang Lin, Ji Zhaochen
Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Haihe Laboratory of Modern Chinese Medicine, Tianjin, China.
Front Pharmacol. 2025 Jul 30;16:1600460. doi: 10.3389/fphar.2025.1600460. eCollection 2025.
The aim of this study is to review the recent studies on the pharmacology and mechanism of action of Went, analyze its medicinal value, and explore future research directions.
A scoping review was conducted by searching the China National Knowledge Infrastructure (CNKI), Wanfang database, VIP database, SinoMed, and PubMed from inception until September 2024. The basic information of the included studies, such as study types, disease types, main components, outcomes, and efficacy, was reviewed and summarized. Methodological quality was assessed using the SYRCLE's risk of bias assessment tool for animal studies and the Cochrane risk of bias assessment tool for clinical trials.
We identified 251 studies from the five databases. Among them, 153 were experimental studies, 70 were reviews, and 28 were clinical trials. Of the experimental studies, molecular studies accounted for the largest portion, totaling 80 (52%). Among the reviews, research progress accounted for the most, totaling 41 (59%). The clinical trials studied the effects of Went and its related Chinese patent medicines and preparations. Of these, 17 (61%) used Wentrelated Chinese patent medicines and preparations as interventions and 11 (39%) used traditional Chinese medicine (TCM) formulations of Went as interventions. In terms of methodological quality, both animal studies and clinical trials related to Went showed deficiencies in randomized allocation sequence generation, allocation concealment, and blinding methods.
We summarized existing studies on the active ingredients and effects of Went and found that it is necessary to improve the generation of random allocation sequences and the application of the blinding method in Went-related animal studies and clinical trials. When similar studies are conducted in the future, the specific methods of random assignment should be more clearly described, and blinding methods should be applied to improve the objectivity and accuracy of the studies, thereby providing a reference for selecting future research directions and establishing supporting evidence.
本研究旨在综述温莪术药理学及作用机制的近期研究，分析其药用价值，并探索未来研究方向。
通过检索中国知网（CNKI）、万方数据库、维普数据库、中国生物医学文献数据库（SinoMed）以及PubMed，进行范围综述，检索时间从建库至2024年9月。对纳入研究的基本信息，如研究类型、疾病类型、主要成分、结局及疗效等进行回顾与总结。采用SYRCLE动物研究偏倚风险评估工具和Cochrane临床试验偏倚风险评估工具评估方法学质量。
我们从五个数据库中识别出251项研究。其中，153项为实验研究，70项为综述，28项为临床试验。在实验研究中，分子研究占比最大，共计80项（52%）。在综述中，研究进展占比最多，共计41项（59%）。临床试验研究了温莪术及其相关中成药和制剂的效果。其中，17项（61%）使用温莪术相关中成药和制剂作为干预措施，11项（39%）使用温莪术的中药配方作为干预措施。在方法学质量方面，与温莪术相关的动物研究和临床试验在随机分配序列生成、分配隐藏和盲法方面均存在不足。
我们总结了温莪术活性成分和作用的现有研究，发现有必要改进温莪术相关动物研究和临床试验中随机分配序列的生成以及盲法的应用。未来进行类似研究时，应更清晰地描述随机分配的具体方法，并应用盲法以提高研究的客观性和准确性，从而为选择未来研究方向和建立支持证据提供参考。
