Long Dan, Mao Chenhan, An Haoyu, Zhu Ying, Xu Yin
Department of Gastroenterology, The First Hospital of Hunan University of Chinese Medicine, Changsha, China.
Department of Cardiology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Front Nutr. 2025 Jul 30;12:1594481. doi: 10.3389/fnut.2025.1594481. eCollection 2025.
Cardiovascular-kidney-metabolic (CKM) syndrome represents a major health threat globally. The newly proposed dietary index for gut microbiota (DI-GM), which quantifies dietary quality associated with gut microbiota diversity, may influence the risk of CKM syndrome. Therefore, this study examined the correlation between DI-GM and the prevalence of CKM syndrome, aiming to provide insights for preventive innovation and tailored treatment methods.
This cross-sectional study included 8,400 adults aged 20 years and older from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. The potential association between the DI-GM score and CKM syndrome was evaluated using univariable and multivariable weighted logistic regression models, restricted cubic spline (RCS), and subgroup analyses.
The average age of the participants was 45.5 years, with 52.0% of the participants being male. A higher DI-GM score was significantly associated with a lower prevalence of CKM syndrome (OR = 0.87, 95% CI: 0.81 to 0.92, < 0.001). The RCS analysis further confirmed a linear relationship between DI-GM score and CKM syndrome ( for nonlinear = 0.194). Furthermore, subgroup analysis indicated that sex potentially influenced the association between DI-GM and CKM syndrome ( for interaction = 0.004), with the protective effect being more pronounced among U. S. females.
DI-GM score exhibits an inverse correlation with the risk of CKM syndrome. Optimizing dietary patterns to improve DI-GM is associated with reduced risk of CKM syndrome.
心血管-肾脏-代谢（CKM）综合征是全球主要的健康威胁。新提出的肠道微生物群饮食指数（DI-GM），用于量化与肠道微生物群多样性相关的饮食质量，可能会影响CKM综合征的风险。因此，本研究探讨了DI-GM与CKM综合征患病率之间的相关性，旨在为预防性创新和个性化治疗方法提供见解。
这项横断面研究纳入了2007 - 2018年美国国家健康与营养检查调查（NHANES）中8400名20岁及以上的成年人。使用单变量和多变量加权逻辑回归模型、受限立方样条（RCS）和亚组分析评估DI-GM评分与CKM综合征之间的潜在关联。
参与者的平均年龄为45.5岁，其中52.0%为男性。较高的DI-GM评分与较低的CKM综合征患病率显著相关（OR = 0.87，95% CI：0.81至0.92，< 0.001）。RCS分析进一步证实了DI-GM评分与CKM综合征之间的线性关系（非线性检验P = 0.194）。此外，亚组分析表明性别可能影响DI-GM与CKM综合征之间的关联（交互作用检验P = 0.004），在美国女性中保护作用更为明显。
DI-GM评分与CKM综合征风险呈负相关。优化饮食模式以提高DI-GM与降低CKM综合征风险相关。
