通过临床级方案在可生物降解支架上恢复源自基因校正的视网膜色素变性诱导多能干细胞的视网膜色素上皮细胞片的吞噬能力：对自体治疗的意义。 - Suppr | 超能文献

Restored phagocytic ability of RPE patches derived from gene-corrected retinitis pigmentosa-hiPSCs on a biodegradable scaffold via clinical-grade protocol: Implications for autologous therapy.

作者信息

Francisco Javier Rodriguez-Jimenez, Ana Artero-Castro, Hana Studenovska, Francisca Selles, Alba Maria Arteaga Claramunt, Anna Brymova, Pavla Jendelova, Jan Motlik, Goran Petrovski, Lyubomyr Lytvynchuk, Taras Ardan, Lucie Tichotová, Saskia Drutovič, Ruchi Sharma, Dunja Lukovic, Kapil Bharti, Slaven Erceg

机构信息

Stem Cells Therapies in Neurodegenerative Diseases Lab, Centro de Investigación Principe Felipe (CIPF), Valencia 46012, Spain.

Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague 16206, Czech Republic.

出版信息

Genes Dis. 2025 Mar 22;12(6):101609. doi: 10.1016/j.gendis.2025.101609. eCollection 2025 Nov.

DOI:10.1016/j.gendis.2025.101609

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12343362/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b8c/12343362/635dfc6d06fe/gr1.jpg

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Subretinal Implantation of Human Primary RPE Cells Cultured on Nanofibrous Membranes in Minipigs.纳米纤维膜培养的人原代视网膜色素上皮细胞在小型猪中的视网膜下植入

Biomedicines. 2022 Mar 14;10(3):669. doi: 10.3390/biomedicines10030669.

3

Gene Correction Recovers Phagocytosis in Retinal Pigment Epithelium Derived from Retinitis Pigmentosa-Human-Induced Pluripotent Stem Cells.基因矫正恢复源于色素性视网膜炎-人诱导多能干细胞的视网膜色素上皮细胞的吞噬作用。

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Generation of gene-corrected human induced pluripotent stem cell lines derived from retinitis pigmentosa patient with Ser331Cysfs*5 mutation in MERTK.从患有MERTK基因Ser331Cysfs*5突变的视网膜色素变性患者中生成基因校正的人诱导多能干细胞系。

Stem Cell Res. 2019 Jan;34:101341. doi: 10.1016/j.scr.2018.11.003. Epub 2018 Nov 16.

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