Huang Jiashun, Zhong Feifei, Liu Bo, Chen Xi, Guo Xin
Department of Cardiovascular Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
J Thorac Dis. 2025 Jul 31;17(7):4746-4757. doi: 10.21037/jtd-2025-86. Epub 2025 Jul 29.
Heart failure (HF) is a prevalent cardiovascular disease exhibiting a complex interplay with dietary vitamin intake. This study employed a comprehensive methodology to investigate the association between exposure to single and multiple dietary vitamins and the risk of HF, with the ultimate goal of providing an evidence-based framework for HF prevention and management strategies.
Data on subjects over the age of 18 years were extracted from the 2009 to 2014 National Health and Nutrition Examination Survey (NHANES). Three different covariate-adjusted models were constructed to analyze the single effects of dietary vitamins A, C, D, K, B6, B12, B1 and B2 intake on HF. The dose-response relationship between each vitamin and HF risk was analyzed via a restricted cubic spline (RCS).
This study enrolled 13,025 subjects and categorized them into the non-HF (N=12,623) and the HF (N=402) groups. The HF group exhibited a lower intake of vitamins A, K, B6, B1 and B2 compared with the non-HF group (P<0.05). The fully adjusted model demonstrated a negative association of the intake of vitamins A [odds ratio (OR): 0.750, 95% confidence interval (CI): 0.565, 0.997], K (OR: 0.702, 95% CI: 0.523, 0.942), D (OR: 0.715, 95% CI: 0.535, 0.955), B12 (OR: 0.703, 95% CI: 0.533, 0.927), B1 (OR: 0.680, 95% CI: 0.489, 0.946), and B2 (OR: 0.673, 95% CI: 0.490, 0.925) with HF. An obvious association of high levels of vitamins A, K, B1 and B2 with a reduced probability of HF was found across the three models (all P<0.05). The RCS analysis revealed a linear correlation between vitamins K, B6, B1, B2 and HF (P for nonlinear >0.05, P for overall <0.05).
HF risk was found to decrease with increasing intake of dietary vitamins A, K, B1 and B2. There was a negative correlation of vitamins K, B6, B1, B2 intake with HF.
心力衰竭（HF）是一种常见的心血管疾病，与膳食维生素摄入之间存在复杂的相互作用。本研究采用综合方法调查单一和多种膳食维生素暴露与HF风险之间的关联，最终目标是为HF预防和管理策略提供循证框架。
从2009年至2014年美国国家健康与营养检查调查（NHANES）中提取18岁以上受试者的数据。构建三种不同的协变量调整模型，以分析膳食维生素A、C、D、K、B6、B12、B1和B2摄入对HF的单一影响。通过限制性立方样条（RCS）分析每种维生素与HF风险之间的剂量反应关系。
本研究纳入13,025名受试者，将其分为非HF组（N = 12,623）和HF组（N = 402）。与非HF组相比，HF组维生素A、K、B6、B1和B2的摄入量较低（P < 0.05）。完全调整模型显示，维生素A [比值比（OR）：0.750，95%置信区间（CI）：0.565，0.997]、K（OR：0.702，95% CI：0.523，0.942）、D（OR：0.715，95% CI：0.535，0.955）、B12（OR：0.703，95% CI：0.533，0.927）、B1（OR：0.680，95% CI：0.489，0.946）和B2（OR：0.673，95% CI：0.490，0.925）的摄入量与HF呈负相关。在三种模型中均发现维生素A、K、B1和B2水平较高与HF发生概率降低存在明显关联（均P < 0.05）。RCS分析显示维生素K、B6、B1、B2与HF之间存在线性相关性（非线性P > 0.05，总体P < 0.05）。
发现HF风险随着膳食维生素A、K、B1和B2摄入量的增加而降低。维生素K、B6、B1、B2的摄入量与HF呈负相关。
